Molecular Therapy, 2009 · DOI: 10.1038/mt.2009.23 · Published: June 1, 2009
This study explores a new approach to treat sensory defects after brachial plexus injury by combining microsurgery and gene therapy. The study focuses on regenerating central axons of dorsal root ganglion neurons, which are crucial for sensory information transmission. Microsurgery was used to restore anatomical continuity between injured and intact dorsal roots using nerve grafts. Gene therapy was employed to deliver neurotrophic factors (NT-3 and GDNF) to stimulate axonal regrowth in the nerve graft. The results showed that the combined treatment led to efficient regeneration of central axons into the spinal cord, resulting in partial recovery of nociception and proprioception. This suggests a promising method for reducing somatosensory defects after brachial plexus injury.
Offers a novel approach to improve sensory repair after brachial plexus injury, which is often a challenge with current surgical methods.
The combination of microsurgery and gene therapy enhances axonal regeneration and functional recovery, potentially leading to better patient outcomes.
The study provides a foundation for translating this combined treatment approach into clinical practice to reduce disability from somatosensory defects.