Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,671-11,680 of 12,052 results
Journal of NeuroEngineering and Rehabilitation, 2009 • June 16, 2009
This review examines various control strategies for robotic therapy devices used in neurorehabilitation, focusing on assistive, challenge-based, haptic simulation, and coaching approaches. Active assi...
KEY FINDING: The review identifies four categories of active assistance control strategies: impedance-based, counterbalance-based, EMG-based, and performance-based adaptive assistance.
J Physiol, 2009 • June 15, 2009
The review explores central nervous system regeneration in leeches and neonatal opossums to understand the mechanisms that promote and prevent regeneration, contrasting these with the limited regenera...
KEY FINDING: Leech CNS regeneration involves microglial cells and nitric oxide, which facilitate axon regrowth and reconnection with appropriate synaptic targets.
PLoS ONE, 2009 • June 15, 2009
The study demonstrates the feasibility of using brain-controlled functional electrical stimulation (FES) to restore voluntary control of paralyzed muscles in monkeys. The monkeys were able to use neur...
KEY FINDING: Monkeys with temporary arm paralysis were able to significantly increase their wrist flexion force using brain-controlled FES compared to their force output without FES.
TheScientificWorldJOURNAL, 2009 • June 12, 2009
The use of murine models of SCI has drastically increased in the last decade and, again, significant findings were made in 2008. Insights were provided into mechanisms underlying secondary degeneratio...
KEY FINDING: Two new mouse models of SCI using either graded forceps or Allen’s weight drop system were developed.
Neurosci Lett, 2009 • June 12, 2009
Transplantation of OECs or SCs into demyelinated or traumatic spinal cord injuries can improve functional outcome. The formation of cellular tunnels by OECs in the transected spinal cord through which...
KEY FINDING: OECs build unique cellular tunnels through which axons regenerate across a spinal cord transection lesion site.
Neurosci Lett, 2009 • June 12, 2009
Spinal cord injury (SCI) results in direct mechanical trauma followed by secondary responses, leading to paralysis and loss of sensation. Current treatment options are inadequate, necessitating therap...
KEY FINDING: SCs can fill cystic cavities, increase white matter sparing, myelinate axons, and promote axonal regeneration in various SCI models.
PNAS, 2009 • June 9, 2009
The study uses 2-photon microscopy to monitor vascular and axonal network changes in living mice after spinal cord lesion, observing regrowth of injured axons and transient upregulation of blood vesse...
KEY FINDING: Injured axons show early explorative sprouting, resulting in extensive regrowth until and past the lesion site within 2 months.
Curr Biol, 2009 • June 9, 2009
The mammalian CNS typically does not regenerate well after injury. However, prior research showed that a 'conditioning lesion' to peripheral axons of dorsal root ganglion (DRG) neurons can promote reg...
KEY FINDING: DRG neurons can be conditioned peripherally even after a central lesion has occurred, upregulating regeneration-associated genes (RAGs) similarly to conditioning before CNS injury.
Exp Neurol, 2009 • June 1, 2009
This study presents a straight alley version of the BBB locomotor scale for assessing hindlimb motor function in rats after spinal cord injury. The method involves training rats to ambulate in a rewar...
KEY FINDING: BBB scores in the open field and straight alley were highly correlated (r=0.90), validating the straight alley for locomotor assessment.
Exp Neurol, 2009 • June 1, 2009
This study investigates the expression of RGM and its receptor neogenin in the sea lamprey spinal cord after injury. It aims to understand their roles in axon regeneration, which occurs in lampreys bu...
KEY FINDING: RGM mRNA is expressed in the spinal cord of sea lampreys, primarily in neurons of the lateral gray matter and dorsal cells.