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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 101-110 of 12,052 results

NeurologyRehabilitationBiomedical

Comfort, consistency, and efficiency of garments with textile electrodes versus hydrogel electrodes for neuromuscular electrical stimulation in a randomized crossover trial

Scientific Reports, 2025 • February 20, 2025

This study compared textile electrodes embedded in garments to self-adhesive hydrogel electrodes for neuromuscular electrical stimulation, focusing on comfort, temporal consistency, efficiency, and el...

KEY FINDING: No significant difference was found between textile electrodes with lotion and hydrogel electrodes in terms of comfort (burning sensation intensity and maximum tolerable intensity).

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Spinal Cord InjuryPublic Health

Neglect, Recklessness, and Deliberate Indifference in the Face of a Serious Neurosurgical Pathology: Lessons From the Tragic Fate of Prisoner Elliot Earl Williams

Annals of Surgery Open, 2025 • February 20, 2025

The article presents a comprehensive medical review of the case of Elliot Earl Williams, a US veteran who died in a Tulsa County jail due to severe neglect and deliberate indifference toward a neurosu...

KEY FINDING: Elliott Earl Williams suffered a cervical spine trauma in jail and was not provided adequate or timely medical care, leading to quadriplegia and death.

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Spinal Cord InjuryImmunologyGenetics

Exploration of Hub Genes and Immune Cell Infiltration Characteristics Associated With Spinal Cord Injury in Mice

Journal of Inflammation Research, 2025 • February 20, 2025

In the present study, we statistically analyzed the DEGs between SCI and normal tissue in the GSE5296 and GSE47681 datasets to obtain DEGs. The exploration of the relevance of differential genetic, bi...

KEY FINDING: A total of 522 DEGs were filtered. Enrichment analysis of their biological functions and pathways yielded the most closely related results for inflammatory response, regulation of cytokine production, neutrophil chemotaxis and degranulation, angiogenesis, cell death, TNF signaling pathway, and osteoclast differentiation.

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NeurologyGenetics

Disruption of Extracellular Matrix and Perineuronal Nets Modulates Extracellular Space Volume and Geometry

The Journal of Neuroscience, 2025 • February 19, 2025

This study investigates the effects of disrupting perineuronal nets (PNNs) and diffuse extracellular matrix (dECM) on brain diffusibility using 4-methylumbelliferone (4-MU), an inhibitor of hyaluronan...

KEY FINDING: Oral treatment with 4-methylumbelliferone (4-MU) downregulated PNNs, HA, chondroitin sulfate proteoglycans, and glial fibrillary acidic protein.

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PhysiologyOrthopedicsRehabilitation

Neurophysiology of ACL Injury

Orthopedic Reviews, 2025 • February 18, 2025

ACL injuries disrupt neural connectivity, sensory processing, and motor control, affecting the CNS and necessitating comprehensive rehabilitation. Neuroplastic therapy addresses neuromuscular and neur...

KEY FINDING: ACL injuries disrupt the sensorimotor control of the knee, affecting proprioceptive accuracy, muscular reflexes, and motor control strategies.

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NeurologyOrthopedicsBioinformatics

Serum S100-Beta as a Biomarker for Neurological Recovery in Acute Spinal Cord Injury (ASCI): A Prospective Case-Control Study

Cureus, 2025 • February 18, 2025

This prospective case-control study evaluated serum S100B levels in ASCI patients and healthy controls to assess its potential as a biomarker for injury severity and neurological recovery. The study f...

KEY FINDING: Serum S100B levels in ASCI patients were significantly higher than controls at baseline and two weeks, normalizing after six weeks.

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NeurologyRehabilitation

Effect of high-intensity exercise training on functional recovery after spinal cord injury

Frontiers in Neurology, 2025 • February 17, 2025

This review examines the impact of high-intensity exercise training (HIET) on functional recovery after spinal cord injury (SCI), addressing both its positive effects and potential adverse effects. HI...

KEY FINDING: HIET can improve cardiovascular health, enhance neuroplasticity by upregulating BDNF and mTOR, modulate inflammatory responses, and offer benefits for bone density and skeletal muscle.

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Alternative MedicineImmunologyPain Management

Effects of Combined Shinbaro and Celecoxib in a Complete Freund’s Adjuvant-Induced Inflammatory Pain Mouse Model

Journal of Inflammation Research, 2025 • February 17, 2025

This study investigated the synergistic effects of combining Shinbaro and celecoxib in a mouse model of CFA-induced inflammatory pain. The results demonstrated that the combination therapy effectively...

KEY FINDING: The combination of Shinbaro and celecoxib synergistically reduced mechanical hyperalgesia and paw edema in mice with CFA-induced inflammatory pain.

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Spinal Cord InjuryImmunologyGenetics

Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states

Journal of Neuroinflammation, 2025 • February 14, 2025

This study investigates the microglial response from subacute to chronic cervical SCI in rats, finding distinct microglial signatures that overlap between the subacute and chronic periods. The subacut...

KEY FINDING: Subacute SCI is characterized by a disease-associated microglial (DAM) signature, while chronic SCI is highly heterogeneous, with both injury-induced and homeostatic states.

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Assistive TechnologyRehabilitationSocial Support

Development and content validity of the caregiver assisted transfer technique instrument

Assist Technol, 2025 • February 14, 2025

This study developed and evaluated the content validity of the Caregiver Assisted Transfer Technique Instrument (CATT), designed to objectively assess transfer techniques used by informal caregivers. ...

KEY FINDING: Items were generally rated favorably for importance, clarity, and appropriateness.

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