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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 91-100 of 12,052 results

AnesthesiologyPharmacologySurgery

The Role of Desflurane in the Functional Outcomes Among Spinal Cord Injury Patients Undergoing Upper Extremity Nerve Transfer Procedures

Cureus, 2025 • February 22, 2025

This retrospective study examined the impact of volatile anesthetics (desflurane vs. sevoflurane) on functional outcomes in cervical SCI patients undergoing upper extremity nerve transfer procedures. ...

KEY FINDING: The desflurane group had greater median motor strength than the sevoflurane group towards the final follow-up when the desflurane group had median motor strength of 3 [interquartile range (IQR): 1-4] and sevoflurane group had a median motor strength of 1 (IQR: 0-2.25); p=0.014.

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Spinal Cord InjuryUrologyImmunology

The Current Epidemiology of Urinary Incontinence and Urinary Tract Infections After Spinal Cord Injury—A Model Systems Spinal Cord Injury Examination (2016–2021)

J. Clin. Med., 2025 • February 21, 2025

The study provides a current snapshot of the frequency of urinary incontinence (UI) and urinary tract infections (UTIs) in the spinal cord injury (SCI) population using data from the National Spinal C...

KEY FINDING: Approximately 40% reported UI in the past month and over 50% had a UTI requiring antibiotics in the past year.

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Spinal Cord InjuryAssistive TechnologyNeurorehabilitation

Impact of an upper limb motion-driven virtual rehabilitation system on residual motor function in patients with complete spinal cord injury: a pilot study

Journal of NeuroEngineering and Rehabilitation, 2025 • February 21, 2025

This study investigates the use of a VR system to improve residual motor function in patients with complete SCI, aiming to enhance the sensitivity of sEMG assessments. The VR system uses upper limb mo...

KEY FINDING: Most patients showed significant electromyographic improvements in activation frequency during or after VR training.

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NeurologyNeurorehabilitation

Effects of brain-computer interface based training on post-stroke upper-limb rehabilitation: a meta-analysis

Journal of NeuroEngineering and Rehabilitation, 2025 • February 21, 2025

The meta-analysis examined the effectiveness of BCI-based training on upper-limb function in stroke patients, showing considerable improvements in motor impairment and function. BCI-based training's e...

KEY FINDING: BCI-based training significantly improves upper-limb motor function, as measured by the Fugl-Meyer Assessment-Upper Extremity (FMA-UE).

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Spinal Cord InjuryPharmacologyEndocrinology

Treatment of obesity in spinal cord injury with tirzepatide: a case report

Spinal Cord Series and Cases, 2025 • February 21, 2025

Individuals with SCI experience alterations in metabolism that result in increased central obesity, insulin resistance, and dyslipidemia placing them at elevated risk for developing cardiometabolic di...

KEY FINDING: The patient lost 31 pounds after 3 months of tirzepatide treatment and saw improvements in his lipid profile.

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OrthopedicsBioinformatics

Hemi-Versus Total Hip Arthroplasty in Femoral Neck Fractures? Predicting Failure on a 10-Year Data Analysis of the German Arthroplasty Registry (EPRD)

J. Clin. Med., 2025 • February 21, 2025

This study analyzed data from the German Arthroplasty Registry (EPRD) on nearly 100,000 femoral neck fractures to identify survival rates and risk factors for failure following hemiarthroplasty (HA) a...

KEY FINDING: The failure rate was 3.7% for hemiarthroplasties and 5.6% for total hip arthroplasties, with most failures occurring within six weeks after surgery.

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Pain ManagementBiomechanics

Different Spatial Characteristic Changes in Lumbopelvic Kinematics Before and After Fatigue: Comparison Between People with and Without Low Back Pain

Bioengineering, 2025 • February 20, 2025

This study compared lumbopelvic kinematics in individuals with and without low back pain (LBP) before and after fatigue. Repetitive lifting induced fatigue, significantly affecting lumbopelvic kinemat...

KEY FINDING: Fatigue significantly altered lumbopelvic kinematics, specifically anterior/posterior translation and rotation around the z-axis, in both groups.

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ImmunologyNeurologyOrthopedics

The Impact of Nuclear Factor Kappa B on the Response of Microglia in Spinal Cord Injuries

Cureus, 2025 • February 20, 2025

The microglial response to SCI is dynamic and multifaceted, involving a complex interplay of pro-inflammatory and anti-inflammatory processes that influence the outcome of the injury. The role of NF-k...

KEY FINDING: NF-kB signaling greatly influences how microglia respond to SCI, impacting inflammation, tissue damage, and the potential for healing.

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Spinal Cord InjuryRegenerative MedicineGenetics

Mesenchymal stem cells overexpressing neuropeptide S promote the recovery of rats with spinal cord injury by activating the PI3K/AKT/GSK3β signaling pathway

Stem Cell Research & Therapy, 2025 • February 20, 2025

This research investigates the therapeutic potential of nasal mucosa-derived mesenchymal stem cells (EMSCs) modified to overexpress neuropeptide S (NPS) for treating spinal cord injury (SCI) in rats. ...

KEY FINDING: NPS-overexpressing EMSCs showed greater cell survival in the transplanted area compared with stem cells without gene modification within 4 weeks after spinal cord implantation in rats.

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Spinal Cord InjuryNeurologyNeurorehabilitation

Evaluating the health and fitness benefits of a 6-month FES-cycling program on a recumbent trike for individuals with motor complete SCI: a pilot study

Journal of NeuroEngineering and Rehabilitation, 2025 • February 20, 2025

This pilot study investigated the effects of a 6-month FES-cycling program on a recumbent trike for individuals with motor complete SCI, focusing on muscle mass, bone density, autonomic nervous system...

KEY FINDING: The FES-cycling program led to a significant increase in muscle mass of 34% after 6 months of training, which was correlated to improved cycling performance.

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