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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Spinal Disorders Research

Browse the latest research summaries in the field of spinal disorders for spinal cord injury patients and caregivers.

Showing 71-80 of 159 results

NeurologySpinal DisordersResearch Methodology & Design

A rare case of spontaneous giant pneumorrachis presenting with cauda equina syndrome: a case report

Spinal Cord Series and Cases, 2024 • March 27, 2024

This case report describes a rare presentation of spontaneous giant pneumorrachis causing cauda equina syndrome in a 56-year-old male. The patient presented with neurological deficits and was found to...

KEY FINDING: The patient presented with cauda equina syndrome symptoms including difficulty walking, urinary dribbling, reduced perianal sensation, and absent voluntary anal contraction.

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OncologySpinal DisordersResearch Methodology & Design

A Combined Cyto- and Histopathological Diagnostic Approach Reduces Time to Diagnosis and Time to Therapy in First Manifestation of Metastatic Spinal Disease: A Cohort Study

Cancers, 2024 • April 25, 2024

This study evaluated the impact of concurrent cytopathology (CP) analysis alongside histopathology (HP) on the time to diagnosis (TTD) and time to therapy (TTT) in patients undergoing spinal surgery f...

KEY FINDING: The mean time to diagnosis (TTD) with cytopathology (CP) was significantly shorter (1.7 days) compared to histopathology (HP) (8.4 days).

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SurgeryMedical ImagingSpinal Disorders

Analysis of imaging characteristics and effectiveness of cervical spondylotic myelopathy with cervical kyphosis

Chinese Journal of Reparative and Reconstructive Surgery, 2024 • May 1, 2024

This study aimed to explore the imaging characteristics of cervical kyphosis and spinal cord compression in cervical spondylotic myelopathy (CSM) patients with cervical kyphosis and its impact on surg...

KEY FINDING: The location of the cervical kyphosis apex relative to the spinal cord compression point affects the clinical outcomes and sagittal parameters after ACDF.

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SurgerySpinal DisordersBioinformatics

Assessing the predictive capability of machine learning models in determining clinical outcomes for patients with cervical spondylotic myelopathy treated with laminectomy and posterior spinal fusion

Patient Safety in Surgery, 2024 • May 27, 2024

This study aimed to assess the effectiveness of machine learning models (MLMs) in predicting clinical outcomes in CSM patients undergoing LPSF. Analysis using binary logistic regression indicated that...

KEY FINDING: Age, preoperative mJOA scale, and symptom duration were independent predictors of poor clinical outcome.

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SurgerySpinal DisordersBiomechanics

Biomechanical Analysis of Hybrid Artificial Discs or Zero-Profile Devices for Treating 1-Level Adjacent Segment Degeneration in ACDF Revision Surgery

Neurospine, 2024 • June 1, 2024

This study uses finite element analysis to compare different surgical revision strategies for adjacent segment degeneration (ASD) following anterior cervical discectomy and fusion (ACDF). The strategi...

KEY FINDING: The CDA-Cage construct demonstrated the lowest biomechanical responses and ROM ratio at adjacent segments among all RS models, closely approaching or even lower than those in the primary ACDF model.

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AgingPhysiologySpinal Disorders

Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model

Oxidative Medicine and Cellular Longevity, 2021 • September 1, 2021

This study investigates the role of mitochondrial ROS in mechanical stress-induced disc degeneration using a one-strike loading organ culture model. The researchers found that mechanical stress leads ...

KEY FINDING: Mechanical stress induces mitochondrial dysfunction and ROS accumulation in nucleus pulposus (NP) cells. The proportion of ROS-positive cells increased significantly in the first 12 hours after mechanical stress.

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ImmunologyNeurologySpinal Disorders

Cervical intramedullary granuloma of Brucella: a case report and review of the literature

Eur Spine J, 2007 • November 14, 2006

The study presents a rare case of cervical intramedullary brucellar granuloma (IBG) in a 35-year-old female, who had a history of Brucella meningitis and improper medication intake. The patient presen...

KEY FINDING: This case represents the first reported instance of intramedullary granuloma of the cervical spine caused by Brucella. Prior cases involved the thoracic spine or conus medullaris.

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NeurologySpinal DisordersResearch Methodology & Design

We Choose to Call it ‘Degenerative Cervical Myelopathy’: Findings of AO Spine RECODE-DCM, an International and Multi-Stakeholder Partnership to Agree a Standard Unifying Term and Definition for a Disease

Global Spine Journal, 2024 • February 1, 2024

The study aimed to address the inconsistency in the naming and definition of cervical myelopathy caused by degenerative changes to the spine. Through a structured, iterative consensus process involvin...

KEY FINDING: The study selected 'Degenerative Cervical Myelopathy' (DCM) as the unifying term for the condition.

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PulmonologyOrthopedicsSpinal Disorders

Report on the clinical outcomes of using postural drainage with intervertebral space as the main focus for managing thoracolumbar tuberculosis

Medicine, 2025 • January 1, 2025

This clinical case report assesses the outcomes of postural drainage targeting the intervertebral space, combined with chemotherapy, for treating thoracolumbar tuberculosis. Eight cases of thoracolum...

KEY FINDING: Postural drainage focusing on the intervertebral space, combined with chemotherapy, led to significant improvements in erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Visual Analogue Scale (VAS) score, American Spinal Cord Injury Association (ASIA) score, and Oswestry functional index.

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Spinal Cord InjuryCardiovascular ScienceSpinal Disorders

Intractable postural hypotension resulting from cervical pseudomeningocele after a posterior cervical spinal surgery: a case report

Spinal Cord Series and Cases, 2023 • March 29, 2023

This case report highlights an unusual cause of intractable postural hypotension (PH) in a patient with a cervical spinal cord injury (SCI). The patient developed PH that was resistant to conventional...

KEY FINDING: A patient with post-acute cervical SCI suffered from intractable PH resulting from pseudomeningocele causing unfavorable rehabilitation outcomes.

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