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  4. Assessing the predictive capability of machine learning models in determining clinical outcomes for patients with cervical spondylotic myelopathy treated with laminectomy and posterior spinal fusion

Assessing the predictive capability of machine learning models in determining clinical outcomes for patients with cervical spondylotic myelopathy treated with laminectomy and posterior spinal fusion

Patient Safety in Surgery, 2024 · DOI: https://doi.org/10.1186/s13037-024-00403-1 · Published: May 27, 2024

SurgerySpinal DisordersBioinformatics

Simple Explanation

Cervical spondylotic myelopathy (CSM) results from spinal cord compression. Laminectomy with posterior spinal fusion (LPSF) treats CSM patients. This study uses machine learning models (MLMs) to predict clinical outcomes in CSM patients undergoing LPSF. A retrospective analysis was conducted on 329 CSM patients. Neurological outcomes were evaluated using the modified Japanese Orthopaedic Association (mJOA) scale. Machine learning models were used to predict clinical outcome. The RF model identified preoperative mJOA scale, age, symptom duration, and MRI signal changes as significant variables associated with poor clinical outcomes. The study highlights the effectiveness of machine learning models in predicting the clinical outcomes of CSM patients undergoing LPSF.

Study Duration
Jul 2017 to Jul 2023
Participants
329 CSM patients
Evidence Level
Not specified

Key Findings

  • 1
    Age, preoperative mJOA scale, and symptom duration were independent predictors of poor clinical outcome.
  • 2
    The RF model identified preoperative mJOA scale, age, symptom duration, and MRI signal changes as the most crucial variables.
  • 3
    RF demonstrated the highest accuracy of 0.922, followed by SVM at 0.901, k-NN at 0.887, and LR at 0.876.

Research Summary

This study aimed to assess the effectiveness of machine learning models (MLMs) in predicting clinical outcomes in CSM patients undergoing LPSF. Analysis using binary logistic regression indicated that age, preoperative mJOA scale, and symptom duration (p < 0.05) were independent predictors of unfavorable clinical outcomes. This study highlighted the effectiveness of machine learning models in predicting the clinical outcomes of CSM patients undergoing LPSF.

Practical Implications

Prognostic Insights

Machine learning models can forecast clinical outcomes, providing valuable prognostic insights for preoperative counseling.

Postoperative Management

The models can aid in postoperative management strategies based on predicted outcomes.

Personalized Treatment

The study suggests potential for personalized treatment approaches based on factors identified by the machine learning models.

Study Limitations

  • 1
    Retrospective design and reliance on existing medical records may lead to incomplete or missing data.
  • 2
    The study was conducted at a single center, potentially limiting the generalizability of the findings.
  • 3
    Understanding the specific factors driving the predictions of these models can be challenging, potentially affecting their clinical utility and decision-making process.

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