Browse the latest research summaries in the field of spinal disorders for spinal cord injury patients and caregivers.
Showing 1-10 of 159 results
PLoS ONE, 2013 • December 13, 2013
This study successfully isolated a recombinant antibody fragment (scFv) that binds to NCAM1-expressing cells in the intervertebral disc (IVD). This scFv has potential applications in targeted drug del...
KEY FINDING: A human scFv was successfully isolated against the recombinant NCAM1 domain using phage display technology.
Neural Regeneration Research, 2013 • December 1, 2013
This study investigated the use of diffusion tensor imaging (DTI) to quantitatively measure pathological changes in a rat model of chronic cervical spondylotic myelopathy. A novel spongy polyurethane ...
KEY FINDING: The fractional anisotropy value gradually decreased over time (4 hours to 1 week) after spinal cord injury in the rat model.
Global Spine Journal, 2025 • June 27, 2024
This systematic review and meta-analysis evaluated the utility of diffusion tensor imaging (DTI) in diagnosing and assessing degenerative cervical myelopathy (DCM). It analyzed 57 studies involving ov...
KEY FINDING: Fractional anisotropy (FA) values are significantly lower in DCM patients compared to healthy subjects at the maximal compression level.
Anim Models Exp Med, 2025 • January 1, 2025
The study established a rat model of spinal cord compression and decompression to investigate SCII following decompressive cervical laminectomy. The model showed that spinal cord decompression leads t...
KEY FINDING: Spinal cord compression led to abnormal mechanical pain and decreased forepaw grip strength in rats.
Eur J Neurol, 2024 • August 4, 2024
This study investigates noncompressive myelopathy as a rare but severe complication of community-acquired bacterial meningitis, identifying seven cases from a nationwide cohort and reviewing 15 additi...
KEY FINDING: Noncompressive myelopathy was reported in 0.23% of community-acquired bacterial meningitis cases.
BMC Musculoskeletal Disorders, 2024 • November 19, 2024
This retrospective study compared laminoplasty with selective unilateral pedicle screw fixation and laminectomy with bilateral lateral mass screw fixation for treating cervical hyperextension injury c...
KEY FINDING: Both surgical procedures led to significant improvements in postoperative AISA scores compared to preoperative scores, indicating enhanced neurological function after surgery.
Orthopaedic Surgery, 2025 • January 1, 2025
The study introduces and evaluates the C1ZAS technique with an “in-out-in” approach as an alternative to C1 PS placement for AAD patients, especially those with narrow C1 pedicles. The radiographic an...
KEY FINDING: The C1ZAS technique, using an “in-out-in” approach, is a feasible alternative to C1 pedicle screw (PS) placement, particularly in patients with AAD and narrow C1 pedicles.
Journal of Orthopaedic Surgery and Research, 2024 • December 1, 2024
This retrospective study analyzed 90 adult patients with severe rigid scoliosis (SRS) who underwent posterior column osteotomy (PCO) and fusion to identify risk factors for postoperative coronal imbal...
KEY FINDING: Preoperative coronal imbalance (CIB+) is significantly associated with postoperative CIB [OR = 12.414 (95% CI: 2.228, 69.162), P = 0.004].
Scientific Reports, 2025 • January 9, 2025
The study aimed to analyze cervical sagittal alignment changes following growing rod treatment in early-onset scoliosis (EOS) and identify risk factors for cervical imbalance using machine learning. T...
KEY FINDING: Growing rod surgery significantly affects cervical sagittal alignment in EOS patients.
Am J Transl Res, 2024 • December 30, 2024
This review explores the pathogenesis and treatment of scoliosis in adult Type 1 Chiari malformation patients with syringomyelia (CIM-SM), highlighting the complexities of surgical intervention. Key a...
KEY FINDING: Adult CIM patients often have more severe clinical manifestations, including brainstem and cranial nerve compression, leading to scoliosis deformities being overlooked.