Browse the latest research summaries in the field of spinal disorders for spinal cord injury patients and caregivers.
Showing 151-159 of 159 results
BMC Musculoskeletal Disorders, 2024 • August 19, 2024
The study aimed to assess biomechanical changes resulting from OLIF combined with six different internal fixation methods for degenerative spondylolisthesis in the lumbar spine using finite element an...
KEY FINDING: The S-A model had the highest average ROM of six motion modes, followed by LSR, UPS, UCBT, BPS and BCBT.
Journal of Orthopaedic Translation, 2024 • August 22, 2024
This review comprehensively examines the complex relationship between oxidative stress, mitochondrial dysfunction, and IVDD, highlighting potential therapeutic targets and concepts for future research...
KEY FINDING: Excessive ROS causes oxidative damage to DNA, proteins, and lipids within IVD cells, disrupting normal cell signaling and regulation pathways.
Journal of Translational Medicine, 2025 • February 11, 2025
This study investigates the role of Follistatin-like 1 (FSTL1) in nucleus pulposus-derived mesenchymal stem cell (NP-MSC) apoptosis and intervertebral disc degeneration (IVDD). The findings reveal tha...
KEY FINDING: FSTL1 expression is elevated in NP-MSCs from degenerated intervertebral discs in both humans and rats.
Neural Regeneration Research, 2015 • November 1, 2015
The study assessed the potential of diffusion tensor imaging (DTI) for quantitative assessment of compressed lumbosacral spinal nerve roots in patients with lumbosacral stenosis. DTI findings demonstr...
KEY FINDING: DTI showed thinning and distortion in 36 lumbosacral spinal nerve roots (49%) and abruption in 17 lumbosacral spinal nerve roots (23%) in patients with spinal stenosis.
BMJ Case Rep, 2016 • June 3, 2016
This case report describes a patient with myelomalacia (spinal cord damage) in the posterior funiculus associated with a ventral longitudinal intraspinal fluid collection (VLISFC). The underlying caus...
KEY FINDING: The patient presented with myelomalacia located in the posterior funiculus at C3 in addition to the anterior horn from C2 to C4.
Spinal Cord Series and Cases, 2015 • October 8, 2015
This study highlights the increasing prevalence of Charcot spinal arthropathy (CSA) in patients with spinal cord injuries (SCI). It emphasizes the importance of understanding initial symptoms, risk fa...
KEY FINDING: Charcot spinal arthropathy (CSA) is most likely increasing in patients suffering from consequences of spinal cord injury.
Spinal Cord Series and Cases, 2016 • September 15, 2016
This case report highlights the diagnostic challenges in HIV-vacuolar myelopathy, emphasizing that a negative MRI scan does not exclude the condition. The importance of assessing both peripheral and c...
KEY FINDING: A negative or unspecific MRI scan does not rule out HIV-related myelopathy in HIV-positive patients with myelopathy symptoms.
Neurosurgery, 2019 • January 1, 2019
This study investigates the potential of nucleus pulposus (NP)-like cells (NPCs) derived from human umbilical cord mesenchymal stem cells (MSCs) to restore degenerated intervertebral discs (IVDs) usin...
KEY FINDING: NPCs derived from MSCs expressed NP-specific genes (SOX9, ACAN, COL2, FOXF1, and KRT19).
J Korean Neurosurg Soc, 2010 • January 1, 2010
The study aimed to investigate the molecular biologic characteristics of primary and recurrent herniated discs to understand the similarities and differences in their gene expression profiles. The res...
KEY FINDING: mRNA gene expression of recurrent disc cells showed increased expression of aggrecan, type I collagen, type II collagen, Sox-9, osteocalcin, and alkaline phosphatase compared to primary herniated lumbar disc cells.