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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Spinal Disorders Research

Browse the latest research summaries in the field of spinal disorders for spinal cord injury patients and caregivers.

Showing 31-40 of 159 results

GeneticsSpinal Disorders

Research progress on long non‑coding RNAs in non‑infectious spinal diseases (Review)

MOLECULAR MEDICINE REPORTS, 2024 • June 18, 2024

The review explains the classification and functions of lncRNAs and their roles in IDD, AS and SCI, noting their impact on ECM, cell death, inflammation, and aging in spinal diseases. Thousands of lnc...

KEY FINDING: lncRNAs are involved in the occurrence and development of spinal diseases, including IDD, ankylosing spondylitis, and spinal cord injury.

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SurgerySpinal Disorders

Which Is Better in Clinical and Radiological Outcomes for Lumbar Degenerative Disease of Two Segments: MIS-TLIF or OPEN-TLIF?

J. Pers. Med., 2022 • November 30, 2022

This study retrospectively analyzed 112 patients with two-level lumbar degenerative diseases treated with either MIS-TLIF or OPEN-TLIF to compare clinical and radiological outcomes. Results indicated ...

KEY FINDING: The MIS-TLIF group had longer operation times and more intraoperative fluoroscopy times compared to the OPEN-TLIF group.

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Regenerative MedicinePain ManagementSpinal Disorders

Clinical Outcomes of Amniotic Membrane/Umbilical Cord Particulate in Spinal Disorders: A Retrospective Study

Journal of Pain Research, 2022 • December 16, 2022

This retrospective study evaluated the clinical outcomes of amniotic membrane/umbilical cord (AMUC) particulate injections in patients with musculoskeletal spinal disorders. The study found that AMUC ...

KEY FINDING: AMUC injections significantly reduced pain in patients with spinal disorders, with pain scores decreasing as early as two weeks post-injection.

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SurgeryOrthopedicsSpinal Disorders

Analysis of surgical strategies and efficacy in the treatment of Os odontoideum with atlantoaxial dislocation

Journal of Orthopaedic Surgery and Research, 2023 • January 8, 2023

This study retrospectively analyzed 56 patients with os odontoideum (OO) and atlantoaxial dislocation (AAD) to determine effective surgical strategies. AAD was classified into four types, and surgical...

KEY FINDING: OO patients with irreducible AAD can be treated by translateral mass release or transoral release combined with posterior fixation and fusion

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ImmunologyPain ManagementSpinal Disorders

Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration

Int. J. Mol. Sci., 2023 • February 8, 2023

The study investigated the effects of endplate (EP) injuries on spinal cord sensitization and neuroinflammation in rats with intervertebral disc degeneration. Results showed that EP injuries led to in...

KEY FINDING: EP injuries significantly increased SubP, Iba1, and GFAP in the dorsal horn of the spinal cord, indicating spinal cord sensitization and neuroinflammation.

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AgingOrthopedicsSpinal Disorders

Wiltse transforaminal thoracic interbody fusion approach for the treatment of single‑segment thoracic spinal tuberculosis in elderly patients with osteoporosis: A retrospective study of 20 cases

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023 • January 31, 2023

This study evaluated the clinical feasibility and efficacy of the Wiltse TTIF approach in elderly patients with single-segment thoracic tuberculosis complicated with osteoporosis and neurological dysf...

KEY FINDING: The study found that all 20 patients with SSTTB were completely cured without recurrence after undergoing Wiltse TTIF surgery combined with anti-TB chemotherapy.

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SurgerySpinal Disorders

Life expectancy in patients with degenerative cervical myelopathy is currently reduced but can be restored with timely treatment

Acta Neurochirurgica, 2023 • March 1, 2023

This study investigates the impact of degenerative cervical myelopathy (DCM) on life expectancy, comparing survival rates of DCM patients who underwent surgery with an age- and gender-matched cohort f...

KEY FINDING: Patients undergoing surgery for DCM have a reduced life expectancy compared to the general population.

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Spinal Cord InjurySpinal DisordersBioinformatics

Diffusion basis spectrum imaging identifies clinically relevant disease phenotypes of cervical spondylotic myelopathy

Clin Spine Surg, 2023 • April 1, 2023

This study applied a machine learning clustering algorithm to baseline imaging data to identify clinically-relevant CSM patient phenotypes. Using baseline imaging data, we delineated a clinically-mean...

KEY FINDING: The study identified three distinct clusters of CSM patients based on DBSI metrics using k-means clustering.

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SurgerySpinal DisordersResearch Methodology & Design

Aggressive thoracic vertebral hemangioma: case report and literature review

Spinal Cord Series and Cases, 2023 • May 11, 2023

This case report describes a rare instance of an aggressive thoracic vertebral hemangioma in a 39-year-old female, leading to paraplegia and pain. The patient was successfully treated with a combinati...

KEY FINDING: Aggressive vertebral hemangiomas can cause significant pain and neurological symptoms due to spinal cord compression.

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SurgerySpinal DisordersPublic Health

Disparities in anterior cervical discectomy and fusion provision and outcomes for cervical stenosis

North American Spine Society Journal, 2023 • April 14, 2023

Significant disparities exist in the trajectory of cervical stenosis (CS) and the risks associated with anterior cervical discectomy and fusion (ACDF) amongst various demographic cohorts. Lower socioe...

KEY FINDING: White patients were less likely to have severe symptoms like myelopathy, while Black and Hispanic patients were more likely to experience these symptoms.

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