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  4. Clinical Outcomes of Amniotic Membrane/Umbilical Cord Particulate in Spinal Disorders: A Retrospective Study

Clinical Outcomes of Amniotic Membrane/Umbilical Cord Particulate in Spinal Disorders: A Retrospective Study

Journal of Pain Research, 2022 · DOI: https://doi.org/10.2147/JPR.S375201 · Published: December 16, 2022

Regenerative MedicinePain ManagementSpinal Disorders

Simple Explanation

This study explores a new treatment for back pain using injections made from amniotic membrane and umbilical cord tissue (AMUC). The aim was to see if these injections could reduce pain in people with different spinal problems. The study looked back at the medical records of 52 patients who had AMUC injections for their back pain. Researchers checked how the patients' pain levels changed after the injections. The results showed that the AMUC injections did seem to help reduce pain in these patients. The researchers believe this treatment could be a promising option for people suffering from spinal pain.

Study Duration
16 Months
Participants
52 patients with musculoskeletal spinal disorders
Evidence Level
Level IV, Retrospective Study

Key Findings

  • 1
    AMUC injections significantly reduced pain in patients with spinal disorders, with pain scores decreasing as early as two weeks post-injection.
  • 2
    Patients reported improvements in pain, range of motion, or sensation after receiving AMUC injections.
  • 3
    No significant complications or adverse events were noted over the average 10.6 weeks of follow-up, indicating the safety of AMUC injections.

Research Summary

This retrospective study evaluated the clinical outcomes of amniotic membrane/umbilical cord (AMUC) particulate injections in patients with musculoskeletal spinal disorders. The study found that AMUC injections led to a significant reduction in pain. The study included 52 patients with diagnoses such as spondylosis, intervertebral disc degeneration, and radiculopathy. The average baseline pain score was 4.9 ± 2.2, which significantly decreased after AMUC injection. The authors conclude that injectable AMUC may alleviate pain in patients with painful spinal indications of various pathologies and provides further evidence of its safety and efficacy in epidural and facet injections.

Practical Implications

Pain Management Alternative

AMUC injections offer a potential non-opioid alternative for managing chronic back pain, reducing reliance on medications with significant side effects.

Improved Quality of Life

Reduction in pain allows patients to return to activities of daily living and work, improving their overall quality of life.

Regenerative Treatment Option

AMUC's anti-inflammatory and pro-regenerative properties provide a biological approach to repairing spinal joint tissues.

Study Limitations

  • 1
    Single-center study limiting generalizability
  • 2
    Retrospective design with potential for bias
  • 3
    Small sample size, particularly at later follow-up time points

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