Browse the latest research summaries in the field of spinal disorders for spinal cord injury patients and caregivers.
Showing 141-150 of 159 results
Int. J. Mol. Sci., 2023 • April 21, 2023
This review examines the current literature on basic research and emerging clinical applications of PRP therapy for treating spinal diseases, covering in vitro and in vivo studies evaluating PRP's pot...
KEY FINDING: Basic research indicates PRP has promising regenerative potential for intervertebral disc degeneration based on in vitro and in vivo studies.
Neurospine, 2023 • June 1, 2023
This study assessed the relationship between static and dynamic factors and the severity of cervical myelopathy in OPLL patients. The study found that minimal SAC, Cobb angle, total ROM, and local ROM...
KEY FINDING: Minimal space available for the spinal cord (SAC), C2–7 Cobb angle, total range of motion (ROM), and local ROM were identified as independent predictors of myelopathy in OPLL patients.
Front. Mol. Biosci., 2023 • July 14, 2023
The study explores gene signatures and immune cell infiltration related to IDD using bioinformatics analysis. Key findings include the identification of differentially expressed mRNAs, miRNAs, lncRNAs...
KEY FINDING: Identified 346 differentially expressed mRNAs, 12 differentially expressed miRNAs, 883 differentially expressed lncRNAs, and 916 differentially expressed circRNAs in the GEO database.
Cells, 2023 • August 28, 2023
This review comprehensively examines methodologies to induce the differentiation of MSCs into IVD cells for regenerative therapies for IDD, focusing on molecules, scaffolds, and environmental factors....
KEY FINDING: TGF-β superfamily members and GDF5 and 6 played key roles in MSC differentiation into NPC-like cells, with BMP-7 and GDF6 being potentially the most effective.
Advanced Science, 2024 • December 25, 2023
The study developed LMGDNPs, injectable hydrogel microspheres, to address the nutrient imbalance and harsh microenvironment in degenerated intervertebral discs (IVD). LMGDNPs promoted cell survival an...
KEY FINDING: LMGDNPs showed a delayed release of lactate oxidase (LOX) and effectively consumed lactate, a harmful metabolic byproduct, creating a more favorable environment for cells.
Journal of Orthopaedic Surgery and Research, 2024 • January 5, 2024
The study introduces a combined anterior transcorporeal and posterior translaminar approach for full endoscopic treatment of mixed-type two-segment cervical disc herniation (MTCDH). The technique aims...
KEY FINDING: Patients experienced significant symptom and pain reduction post-operatively, as indicated by clinical assessment scales.
International Journal of Biological Sciences, 2024 • January 1, 2024
This study demonstrates the depletion of the selective autophagy receptor NBR1 in NPCs during the degeneration process, leading to the buildup of SRBD1 within NPCs, thereby accelerating NPCs senescenc...
KEY FINDING: NBR1 expression is downregulated in degenerative nucleus pulposus cells (NPCs) in human and rat models of intervertebral disc degeneration (IDD).
ACS Nano, 2024 • January 18, 2024
The study introduces MnO2@TMNP, a novel nanomaterial designed to address disc degeneration and discogenic pain by targeting inflammation and promoting tissue regeneration. MnO2@TMNP's macrophage membr...
KEY FINDING: MnO2@TMNP effectively binds inflammatory factors and nerve growth factors, inhibiting inflammation-induced apoptosis and nerve ingrowth.
JOR Spine, 2024 • January 1, 2024
This study examines the impact of repetitive violent injuries on intervertebral disc degeneration (IVDD) using an organ culture model. The results indicate that repetitive high-force loading leads to ...
KEY FINDING: Repetitive one strike loading led to early disc degeneration, indicated by decreased dynamic compression stiffness.
Tissue Eng Regen Med, 2024 • April 5, 2024
The study investigates cell therapy for syringomyelia using MSCs and iNSCs in a rat model with focal dilatation of the central canal, aiming to reduce cavity size and alleviate neuropathic pain. Resul...
KEY FINDING: Cell transplantation promotes syrinx shrinkage and stimulates ependymal cell proliferation, with effects related to transplantation location; reactions occur only when cells are transplanted into the cavity.