Browse the latest research summaries in the field of spinal disorders for spinal cord injury patients and caregivers.
Showing 131-140 of 159 results
Annals of Translational Medicine, 2021 • May 1, 2021
This study investigates the correlations among lumbar sagittal balance parameters, inter-body cage positioning variables, and adjacent facet joint degeneration following transforaminal lumbar interbod...
KEY FINDING: Patients with AFD aggravation had significantly higher preoperative back pain VAS scores and postoperative ODI scores, indicating greater pain and disability.
Pain Ther, 2021 • September 15, 2021
The study investigated the impact of pedicle screw insertion trajectory on disc height recovery after fusion surgery for degenerative lumbar spondylolisthesis (DLS). The results suggest that the Cauda...
KEY FINDING: Changes in disc height (DH) were significantly associated with lower pedicle screw angle.
Cells, 2022 • February 9, 2022
IVD degenerative disease is a major obstacle to independent and healthy living and an important issue that needs to be addressed and overcome. A number of studies have been performed on cell-based IVD...
KEY FINDING: Cell-based therapies, such as transplanting autologous NP-derived cells, are physiologically natural and avoid graft-versus-host reactions. However, harvesting autologous cells is invasive, and the cell yield is relatively low.
Aging and Disease, 2022 • April 1, 2022
This study investigates the role of CB2R in intervertebral disc degeneration (IVDD) by examining its effects on nucleus pulposus cell (NPC) senescence both in vitro and in vivo. The study found that C...
KEY FINDING: CB2R expression is decreased in degenerated nucleus pulposus (NP) tissues from both human IVDD patients and rat acupuncture IVDD models, while the expression of p16INK4a increased.
Neurospine, 2022 • September 1, 2022
This review aims to describe the involvement of ECM components in the remodeling process of spinal cord injury (SCI) and intervertebral disc degeneration (IVDD). SCI leads to damage to the intact ECM...
KEY FINDING: ECM components demonstrate both regenerative and degenerative potential in the central nervous system.
Oxidative Medicine and Cellular Longevity, 2022 • October 11, 2022
This study used bioinformatics analysis to identify genes associated with mitochondrial dysfunction in intervertebral disc degeneration (IDD). Datasets GSE70362 and GSE124272 were downloaded from the ...
KEY FINDING: Identified 152 differentially expressed genes (DEGs) between IDD patients and healthy controls, including 67 upregulated and 85 downregulated genes.
Orthopaedic Surgery, 2022 • December 1, 2022
This review synthesizes current research on resveratrol's (RSV) effects on intervertebral disc degeneration (IDD). It highlights RSV's potential to address the limitations of current IDD treatments by...
KEY FINDING: RSV exhibits anti-inflammatory effects by inhibiting pro-inflammatory cytokines like IL-1β, IL-6, IL-8, and TNF-α, which ameliorates IDD progression mediated by inflammation.
J. Clin. Med., 2023 • January 2, 2023
The study classified new bone formation in OPLL into plateau-shaped and hill-shaped patterns and investigated related factors, including serum hs-CRP levels and SI joint ankylosis. The research found ...
KEY FINDING: The plateau shape of OPLL was more common in vertebral segments, while the hill shape was predominant in intervertebral regions.
Quantitative Imaging in Medicine and Surgery, 2023 • March 1, 2023
This retrospective study analyzed 57 patients with degenerative lumbar spondylolisthesis (DLS) and lumbar degenerative scoliosis who underwent single-level unilateral transforaminal lumbar interbody f...
KEY FINDING: TLIF surgery appears effective in improving radiographic and clinical outcomes for patients with DLS and lumbar degenerative scoliosis.
International Journal of Surgery, 2023 • March 31, 2023
The study aimed to evaluate spinal cord blood flow status after sufficient decompression by intraoperative contrast-enhanced ultrasonography (CEUS) and to analyze the correlation between neurological ...
KEY FINDING: Intraoperative CEUS can clearly reflect spinal cord blood flow in DCM patients.