Research Methodology & Design Research

KEY FINDING: Intrathecal delivery of activated Tregs reduced mechanical pain hypersensitivity and improved exploratory behaviors in both male and female mice following chronic constriction injury (CCI) of the sciatic nerve.

KEY FINDING: Biobanking facilitates the identification of genetic variations, epigenetic modifications, and gene expression patterns associated with neurogenic lower urinary tract dysfunction, which are symptoms of neurological diseases.

KEY FINDING: Significant differences exist between clinical care for human SCI patients and veterinary care for experimental animals, particularly in analgesia, anticoagulation, and stress ulcer prophylaxis.

KEY FINDING: Research in immunology for SCI has shifted toward “extracellular vesicles,” “regenerative medicine,” “stromal cells,” “motor recovery,” and “glial activation” as new directions for investigation.

KEY FINDING: Acute traumatic SCI combined with foreign matter retention is rare.

KEY FINDING: The macaque with a 1/4 spinal cord transection injury showed dysfunction in sensation, movement, and partial reflexes.

KEY FINDING: Ara-C treatment, intended to inhibit the growth of non-neuronal cells, also negatively affected the neurons themselves, showing toxicity and inhibiting their growth.

KEY FINDING: The patient presented with right hemiparesis and left-sided paresthesia during an active COVID-19 infection, confirmed by PCR.

KEY FINDING: Spinal cord injury significantly decreased the richness and evenness of intestinal flora in experimental animals.

KEY FINDING: MRI was crucial in diagnosing traumatic hemorrhagic myelopathy in the cervical spinal cord of the dog without vertebral fractures or luxation.