Development of an innovative minimally invasive primate spinal cord injury model: A case report

Spinal cord injuries are a significant problem, and researchers are constantly seeking better ways to study and treat them. Animal models, especially those using primates, are crucial for this research because of their similarity to humans. This study introduces a new, less invasive method of creating spinal cord injuries in macaques, aiming to improve postoperative care and recovery. The researchers created a specific type of spinal cord injury in a macaque, called a dorsal 1/4 spinal cord transection. This method aims to reduce severe complications and improve the animal's well-being after surgery. Because macaques share similar genetics and physiology with humans, this model could provide valuable insights into potential treatments for human spinal cord injuries. The effectiveness of the new injury model was assessed by observing the macaque's walking ability and hindlimb function. The results showed that the model successfully induced motor and sensory deficits, while minimizing the risks associated with more severe injury models. This innovative approach could be highly beneficial for advancing spinal cord injury research.

• 1
  The macaque with a 1/4 spinal cord transection injury showed dysfunction in sensation, movement, and partial reflexes.
• 2
  After successful modeling, the left lower limb showed sensory–motor deficits and could not move on its own, with no complete contraction of the hip–knee and ankle joints.
• 3
  Partial loss of right subcostal sensation (mainly pain and warmth) and partial loss of upper, middle, and lower abdominal wall reflexes on the left side were observed.