Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 61-70 of 702 results
Cureus, 2023 • April 22, 2023
The case report highlights a rare instance of fungal spondylodiscitis caused by Candida albicans in a 52-year-old female patient with a complex medical history. The patient's condition was complicated...
KEY FINDING: Candida albicans was identified as the causative agent of spondylodiscitis in this patient, highlighting the importance of considering fungal etiologies in such infections.
Translational Neuroscience, 2023 • April 24, 2023
The study introduces a newly developed, cost-effective spinal cord impactor device designed for creating consistent spinal cord injuries in rats. This device allows for precise control over the height...
KEY FINDING: A custom-made spinal cord impactor device was successfully developed, allowing for precise adjustment of impact height and displacement.
Rev Bras Ortop, 2023 • August 2, 2022
The study evaluated the current practice of using methylprednisolone sodium succinate (MPSS) in acute spinal cord injuries (ASCIs) among spine surgeons from Iberolatinoamerican countries. A survey was...
KEY FINDING: Only 37.9% of surgeons reported using corticosteroids in the initial management of ASCIs.
Journal of Neurotrauma, 2023 • September 1, 2023
The RISCIS trial evaluated riluzole's safety and efficacy in acute cervical tSCI but was terminated early due to the COVID-19 pandemic. The primary endpoint was not met, but subgroup analyses showed po...
KEY FINDING: The primary analysis did not achieve the predetermined end-point of efficacy for riluzole, likely related to insufficient power.
Neural Regeneration Research, 2023 • March 31, 2023
This systematic review and meta-analysis comprehensively evaluated the efficacy of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in treating traumatic central nervous system diseases,...
KEY FINDING: MSC-EVs treatment significantly promoted motor function recovery in spinal cord injury animals, based on rat and mouse locomotor rating scales.
Frontiers in Neurology, 2023 • June 6, 2023
This review addresses the variability in animal models of cervical spinal cord injury, focusing on the impact of head and neck positioning on biomechanics and outcomes. The review highlights that neck...
KEY FINDING: Neck position affects the exposed spinal level during contusion injuries, potentially causing variability in observed functional outcomes due to differences in the precise neurological level of injury.
Front. Behav. Neurosci., 2023 • June 7, 2023
This study reviews CatWalk XT data from 91 preclinical mouse studies covering six CNS and PNS disorders to identify commonly reported gait parameters. The review categorizes gait parameters into tempo...
KEY FINDING: Certain gait parameters serve as potential indicators of gait dysfunction across multiple disease models.
J Neurosurg Case Lessons, 2023 • June 19, 2023
The case report presents a rare instance of a 10-year-old female who sustained a non-missile penetrating spinal cord injury (NMPSCI) with a retained foreign body (RFB) bisecting her thoracic spinal ca...
KEY FINDING: Direct withdrawal of a retained foreign body (RFB) in a neurologically intact patient with NMPSCI is a viable treatment option.
Frontiers in Molecular Neuroscience, 2023 • June 13, 2023
This work developed a novel model to investigate pathological outcomes in the spinal cord following exposure to a blast wave, which was motivated by the need for improved clinical outcomes following b...
KEY FINDING: The closed-body model for bSCI was found to be highly repeatable, administering consistent pressure pulses following a Friedlander waveform.
Medicine, 2023 • July 7, 2023
This case report details a rare instance of hematomyelia (spinal cord hemorrhage) in a 40-year-old male with COVID-19. The patient presented with fever, urinary/fecal retention, and lower extremity pa...
KEY FINDING: This case report is the first to document hematomyelia, or spinal cord hemorrhage, associated with COVID-19 infection.