Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 591-600 of 2,298 results
Brain Communications, 2021 • November 13, 2021
Axonal regeneration in the mature CNS is limited by extracellular inhibitory factors. Following dorsal column lesions in mice and optic nerve crushes in rats, elevated levels of extracellular histone ...
KEY FINDING: Elevated levels of histone H3 were detected in human CSF 24 h after spinal cord injury.
Frontiers in Bioengineering and Biotechnology, 2022 • January 4, 2022
This study investigates the potential of GDF11, delivered via a lentiviral vector, to promote nerve regeneration after sciatic nerve injury in rats. The findings demonstrate that GDF11 promotes axonal...
KEY FINDING: GDF11 promotes the axonal growth of DRG cells in vitro, suggesting a direct effect on nerve regeneration.
Neural Regeneration Research, 2022 • September 1, 2022
CSPGs inhibit axon regeneration after SCI by interacting with receptors like PTPσ, LAR, and NgRs, activating RhoA and inactivating Akt signaling pathways. ChABC treatment can remove CSPGs, reactivate ...
KEY FINDING: Digestion of CSPGs with ChABC reduces retrograde apoptotic signaling and enhances true axon regeneration in lampreys after spinal cord transection.
NEURAL REGENERATION RESEARCH, 2022 • February 8, 2022
This study demonstrates that repetitive magnetic stimulation of the spinal cord nerve root induces functional recovery following SCI in rats. NRMS improves the excitability of the sensorimotor pathway...
KEY FINDING: Nerve root magnetic stimulation (NRMS) treatment leads to improved recovery of locomotor function following spinal cord injury (SCI).
Neural Plasticity, 2022 • February 2, 2022
This study explores the effect of the P2Y2 receptor (P2Y2R) on neuronal regeneration and angiogenesis after spinal cord injury (SCI) in rats. SCI animal models were created, and the P2Y2R inhibitor wa...
KEY FINDING: The expression of P2Y2R increases after SCI in rats, suggesting its involvement in the injury response.
International Journal of Molecular Sciences, 2022 • January 23, 2022
This review explores the use of biomaterials for peripheral nerve injury (PNI) and spinal cord injury (SCI), highlighting their potential to promote axonal regeneration and nervous system repair by mi...
KEY FINDING: Biomaterials can be engineered to mimic the extracellular matrix of nerve tissue, providing a scaffold for axonal regeneration and facilitating the delivery of therapeutic agents to the injury site.
CNS Neuroscience & Therapeutics, 2022 • January 30, 2022
This review summarizes research on using Governor Vessel electro-acupuncture (GV-EA) combined with adult stem cell transplantation to repair spinal cord injuries (SCI). GV-EA improves the microenviron...
KEY FINDING: GV-EA can stimulate nerve endings, causing them to release substances that promote the survival and differentiation of transplanted stem cells at the injury site.
Cells, 2022 • February 16, 2022
Stem cell therapies have shown promise in the acute-to-subacute phase of SCI, but are less effective in the chronic phase due to tissue remodeling. Regenerative rehabilitation, combining regenerative ...
KEY FINDING: Regenerative rehabilitation can directly influence transplanted cells, promoting differentiation into neurons and oligodendrocytes, and inducing plastic changes in the lumbar enlargement of the spinal cord.
Bone Research, 2022 • October 11, 2022
This study investigates the cellular origin of neurogenic heterotopic ossifications (NHOs), which frequently develop in muscles after spinal cord injuries (SCIs). Using lineage-tracing experiments in ...
KEY FINDING: NHOs developing after SCI in injured muscles in mice are not derived from muscle SCs. We also reveal that NHOs only develop in areas of the injured muscle where SCs fail to regenerate myofibers.
Advanced Science, 2022 • March 4, 2022
This systematic review supports the idea that medical gases can protect cells against common diseases by controlling oxidation, inflammation, and cell death. Carbon monoxide can help restore nerve func...
KEY FINDING: Medical gases like carbon monoxide (CO) and xenon (Xe) show promise in protecting tissues and improving function, particularly in the central nervous system (CNS), heart, retina, liver, kidneys, and lungs.