P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord Injury

This study investigates the role of the P2Y2 receptor (P2Y2R) signaling pathway in neuronal regeneration and angiogenesis following spinal cord injury (SCI) in rats. Researchers created SCI models in rats and then used a P2Y2R inhibitor to observe its effects on inflammation, cell death, and the growth of new blood vessels and nerve cells. The experiments involved assessing motor function, examining spinal cord tissue under a microscope, measuring cell death, and detecting the levels of various proteins and inflammatory molecules. The results suggest that inhibiting P2Y2R may reduce inflammation, prevent cell death, and promote the regeneration of nerve cells and blood vessels in the injured spinal cord. The study concludes that the P2Y2R could be a potential therapeutic target for treating SCI. By modulating this receptor, it may be possible to improve recovery after spinal cord injuries by encouraging nerve regeneration and reducing the harmful effects of inflammation and cell death.

• 1
  The expression of P2Y2R increases after SCI in rats, suggesting its involvement in the injury response.
• 2
  Inhibition of P2Y2R reduces neuronal inflammation after SCI, as evidenced by decreased levels of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6.
• 3
  Blocking P2Y2R promotes neuronal differentiation and angiogenesis after SCI, indicated by increased expression of Tuj1, nestin, and CD34.