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  4. Electro-acupuncture and its combination with adult stem cell transplantation for spinal cord injury treatment: A summary of current laboratory findings and a review of literature

Electro-acupuncture and its combination with adult stem cell transplantation for spinal cord injury treatment: A summary of current laboratory findings and a review of literature

CNS Neuroscience & Therapeutics, 2022 · DOI: 10.1111/cns.13813 · Published: January 30, 2022

Alternative MedicineRegenerative MedicineNeurology

Simple Explanation

Spinal cord injuries are hard to treat because the injured area doesn't support its own repair. Researchers are looking at ways to improve this environment to help tissues heal. One method involves using electro-acupuncture (EA), which combines traditional acupuncture with electrical stimulation, to improve the spinal cord's environment. Another approach involves transplanting stem cells to help rebuild damaged nerve circuits and restore function. Combining EA with stem cell transplantation may be more effective than either treatment alone.

Study Duration
Not specified
Participants
Not specified
Evidence Level
Review

Key Findings

  • 1
    GV-EA can stimulate nerve endings, causing them to release substances that promote the survival and differentiation of transplanted stem cells at the injury site.
  • 2
    Increased production of NT-3, a neurotrophic factor, facilitates the regeneration of nerve fibers and myelination, strengthening motor signals and improving limb function.
  • 3
    The combination of GV-EA and gene-modified adult stem cell transplantation is an innovative strategy for SCI treatment.

Research Summary

This review summarizes research on using Governor Vessel electro-acupuncture (GV-EA) combined with adult stem cell transplantation to repair spinal cord injuries (SCI). GV-EA improves the microenvironment of the injured spinal cord by increasing neurotrophic factors and reducing inflammation, protecting neurons and promoting myelination. Combining GV-EA with stem cell transplantation shows promise in stimulating nerve regeneration, enhancing the survival and integration of transplanted cells, and restoring motor function.

Practical Implications

Clinical Application

The findings support the potential clinical use of GV-EA and adult stem cell transplantation for SCI treatment.

Future Studies

The information provides a basis for future studies on the clinical application of GV-EA and adult stem cell transplantation for the treatment of SCI.

Innovative Strategy

The combination of GV-EA and gene-modified adult stem cell transplantation is an innovative strategy for SCI treatment.

Study Limitations

  • 1
    Ethical barriers to NSC transplantation limit its translational potential.
  • 2
    Gap between experimental models and clinical trials.
  • 3
    Host of limitations related to the safety of gene-modified adult stem cell transplantation for therapeutic use.

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