Regenerative Medicine Research

KEY FINDING: Axonal regrowth can occur even after complete SCI, challenging the classical view of the spinal cord as nonregenerative.

KEY FINDING: The study produced an average yield of 87.2 ± 89.2 million cells at passage 2 (P2) and 150.9 ± 129.9 million cells at passage 3 (P3) with high viability and purity.

KEY FINDING: The BC/FB gel formed within 1 minute at 37 °C and released Decorin in a sustained manner for up to 30 days in vitro.

KEY FINDING: The majority of chronic SCI trials in ClinicalTrials.gov do not restrict the maximum post-injury time for trial eligibility.

KEY FINDING: SCI pathophysiology is multifaceted, necessitating treatments that address dynamic interactions between various cell types. Stem cells are suited for this purpose due to their ability to duplicate, differentiate, and secrete trophic factors.

KEY FINDING: Stem cells can differentiate into neural cells and produce growth factors that promote neuronal survival and axonal regrowth in the SCI microenvironment.

KEY FINDING: Continuous OFS for more than 6 weeks effectively promotes motor function recovery in rats with spinal cord injury.

KEY FINDING: Regenerative rehabilitation can be categorized into conditioning/reconditioning, functional training, and physical exercise, which are indispensable for enhancing functional recovery achieved using stem cell therapies.

KEY FINDING: Successful transplant-mediated repair appeared to be possible using both low and high proportions of OECs in olfactory transplants.

KEY FINDING: Significant differences were observed in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values before and after treatment in the experimental group (P < 0.05).