Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 601-610 of 2,298 results
Frontiers in Neuroscience, 2022 • February 17, 2022
This review focuses on the potential of Schwann cell (SC) transplantation as a therapeutic strategy for spinal cord injury (SCI). SCs offer multiple benefits, including enhancement of axon regeneratio...
KEY FINDING: SCs enhance axon regeneration through secretion of neurotrophic factors (NGF, BDNF, CNTF, and NT-3) and expression of adhesion molecules (L1 and NCAM) and ECM components (laminin, fibronectin, and collagen).
Frontiers in Medical Technology, 2022 • February 22, 2022
This review explores the emerging field of neural stem cell therapy and the engineering of functionalized biomaterials to facilitate cell transplantation and promote regeneration of damaged spinal cor...
KEY FINDING: NSCs are multipotent cells that can self-renew and generate all the specialized neural cells within the spinal cord, that is, neurons, astrocytes and oligodendrocytes.
Frontiers in Molecular Neuroscience, 2022 • April 8, 2022
This study presents a detailed protocol for differentiating human pluripotent stem cells (hPSCs) into spinal dI4 GABAergic interneurons (INs), which are crucial for spinal cord function and potential ...
KEY FINDING: A reproducible protocol was devised to differentiate human pluripotent stem cells (hPSCs) from enriched spinal dI4 inhibitory GABAergic INs.
Neural Regen Res, 2022 • April 1, 2022
Efficient strategies for neuroprotection and repair are still an unmet medical need for neurodegenerative diseases and lesions of the central nervous system. Over the last few decades, a great deal of...
KEY FINDING: OPCs are the most abundant proliferative population in the adult CNS, representing 5–8% of all cells, and can be recognized by the expression of membrane markers such as NG2 and PDGF.
Neural Regeneration Research, 2022 • December 1, 2022
This study investigated the potential of sodium selenite (SS) to promote neurological function recovery after spinal cord injury (SCI) by inhibiting ferroptosis in a rat model. The results showed that...
KEY FINDING: Sodium selenite treatment decreased iron concentration and levels of the lipid peroxidation products malondialdehyde and 4-hydroxynonenal in a rat model of spinal cord injury.
Cureus, 2022 • April 28, 2022
This review summarizes recent clinical trials investigating stem cell therapies for spinal cord injury (SCI). It discusses the pathophysiology of SCI and mechanisms of action of different stem cells. ...
KEY FINDING: Mesenchymal stem cells (MSCs) have shown promise due to their anti-apoptotic, neurotrophic, neuroprotective, and immunomodulatory effects.
STAR Protocols, 2022 • June 17, 2022
The protocol details a method for isolating and comparing neural stem cells (NSCs) from the adult rat brain and spinal cord canonical neurogenic niches. It involves tissue dissection, dissociation, ce...
KEY FINDING: The protocol provides a unified method for extracting NSCs from three neurogenic niches: the subventricular zone (SVZ), subgranular zone (SGZ), and central canal (CC).
Signal Transduction and Targeted Therapy, 2022 • April 6, 2022
This study investigates the effectiveness of NT3-chitosan in repairing chronic spinal cord injury (SCI) in rats. The researchers used MR-DTI to monitor lesion area changes and found that NT3-chitosan'...
KEY FINDING: Clearance of the lesion core (via suction of cystic tissues and trimming of solid scar tissues) before introducing NT3-chitosan led to robust neural regeneration and functional recovery.
Journal of Neuroinflammation, 2022 • June 5, 2022
This study investigates the role of Apelin in treating spinal cord injury (SCI) by reducing neuroinflammation and promoting neural stem cell (NSC) proliferation and differentiation. The researchers fo...
KEY FINDING: Apelin expression decreases after SCI and then increases later, suggesting its involvement in both injury and repair.
ANNALS OF MEDICINE, 2022 • June 9, 2022
This study used resting-state fMRI and Granger causality analysis to investigate brain functional reorganization in rhesus monkeys after spinal cord injury (SCI) and neurotrophin-3/chitosan transplant...
KEY FINDING: Spontaneous recovery after SCI follows a pattern of early intra-hemispheric reorganization followed by late inter-hemispheric reorganization, while regenerative therapy shows the opposite trend.