Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 571-580 of 2,298 results
Neural Regen Res, 2021 • August 1, 2021
This review discusses stem cell therapy for spinal cord injury, focusing on induced pluripotent stem cells (iPSCs) and their potential to differentiate into neural cell precursors at the injury site. ...
KEY FINDING: Neurons are responsible for transmitting information throughout the body, and their repair is critical for restoring voluntary movement below the injury site in SCI patients.
Journal of Neurotrauma, 2022 • February 1, 2022
This phase 1 trial assessed the safety and feasibility of autologous human Schwann cell (ahSC) transplantation combined with rehabilitation in chronic SCI patients. The study involved harvesting, cult...
KEY FINDING: The study demonstrated that transplanting autologous human Schwann cells into chronic spinal cord injuries is feasible and appears to be safe.
CNS Neuroscience & Therapeutics, 2021 • February 24, 2021
The study demonstrates that electroacupuncture (EA) as an adjuvant therapy for TrkC-modified mesenchymal stem cell-derived MN increases the local production of NT-3. This increase in NT-3 accelerates ...
KEY FINDING: Electroacupuncture enhances the production of endogenous NT-3 in damaged spinal cord tissues.
The Journal of Spinal Cord Medicine, 2021 • January 1, 2021
This pilot study investigated the safety and efficacy of micro-fragmented adipose tissue (MFAT) injections for treating refractory shoulder pain caused by rotator cuff disease in wheelchair users with...
KEY FINDING: There were no significant adverse events throughout the study period.
J Neurosci Res, 2021 • January 1, 2021
This study compared olfactory ensheathing cell (OEC) transplantation and repetitive trans-spinal magnetic stimulation (rTSMS) individually and in combination as therapies for spinal cord injury (SCI) ...
KEY FINDING: rTSMS has a beneficial effect on modulating spinal scar tissue by reducing fibrosis, demyelination, and microglial cell activation, while increasing the astroglial component of the scar.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021 • February 2, 2021
This study demonstrated that inhibiting STAT3 not only promoted NSC differentiation into neurons, but also inhibited their differentiation into astrocytes, potentially through mTOR activation. The tra...
KEY FINDING: Knocking down STAT3 expression in rat NSCs promoted their neuronal differentiation in vitro, and upregulated the activity of mTOR.
Journal of International Medical Research, 2021 • June 1, 2021
This study evaluated the effectiveness of combining peripheral nerve grafting and acidic fibroblast growth factor (aFGF) infusion in reducing spasticity after spinal cord injury (SCI) in monkeys. The ...
KEY FINDING: The combined therapy of peripheral nerve grafting and aFGF infusion substantially reduced spasticity in leg muscle tone, patella tendon reflex, and fanning of toes in monkeys with SCI.
Stem Cell Research & Therapy, 2021 • January 31, 2021
This study examined the effects of LINGO-1 on spinal cord-derived NSPC (sp-NSPC) differentiation, its mechanisms, and functional recovery in mice after cell transplantation. LINGO-1 shRNA promotes neu...
KEY FINDING: LINGO-1 shRNA increased neuronal differentiation of spinal cord-derived NSPCs while decreasing astrocyte differentiation.
Science Progress, 2021 • July 1, 2021
Spinal cord injury (SCI) disrupts the sensorimotor pathway, leading to autonomic function loss. Research indicates that SCI impacts brain structure and function, highlighting the brain's plasticity. S...
KEY FINDING: SCI causes neuronal death/atrophy in the brain, which might be attributed to a series of biochemical processes.
Neural Regen Res, 2022 • March 1, 2022
This study introduces a high-density flexible electrode array for precise epidural spinal cord stimulation (ESCS) in rats with spinal cord injury (SCI). The research identifies specific spinal cord re...
KEY FINDING: The study identified specific regions in the spinal cord (L1 and L2 vertebral levels) where stimulation effectively activated the vastus lateralis (VL) and medial gastrocnemius (MG) muscles, respectively.