Thermosensitive collagen/fibrinogen gels loaded with decorin suppress lesion site cavitation and promote functional recovery after spinal cord injury

The study focuses on developing a less invasive treatment for spinal cord injuries using injectable, thermosensitive scaffolds. The scaffold, made of bovine collagen and fibrinogen, can deliver drugs like Decorin directly to the injury site. Results showed reduced cavitation, increased cell presence, and improved nerve regeneration with the Decorin-loaded gel.

• 1
  The BC/FB gel formed within 1 minute at 37 °C and released Decorin in a sustained manner for up to 30 days in vitro.
• 2
  Gel + Decorin promoted near 100% survival of DRGN in serum-free conditions and significantly increased neurite outgrowth in vitro.
• 3
  In vivo, Gel + Decorin injections significantly suppressed DC cavity area by 92% compared with PBS and Gel + PBS.