Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 421-430 of 2,298 results
Biomedicines, 2023 • April 13, 2023
This study evaluated the effects of microneurotrophin BNN27, an NGF analog, in a mouse dorsal column crush spinal cord injury (SCI) model. BNN27 was delivered systemically either by itself or combined...
KEY FINDING: Systemic administration of BNN27 significantly reduced astrogliosis in mice SCI lesion sites at 12 weeks post injury.
Stem Cells Translational Medicine, 2023 • May 20, 2023
This study demonstrates that acute metformin treatment can improve functional recovery after spinal cord injury (SCI) in both male and female mice. The drug's effectiveness is linked to its ability to...
KEY FINDING: Acute metformin treatment improves functional outcomes following SCI in both sexes.
Neural Regeneration Research, 2023 • March 31, 2023
This systematic review and meta-analysis comprehensively evaluated the efficacy of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in treating traumatic central nervous system diseases,...
KEY FINDING: MSC-EVs treatment significantly promoted motor function recovery in spinal cord injury animals, based on rat and mouse locomotor rating scales.
Basic and Clinical Neuroscience, 2022 • September 1, 2022
The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating ChABC in improving the complicatio...
KEY FINDING: ChABC administration improves locomotion recovery after SCI.
Chinese Journal of Reparative and Reconstructive Surgery, 2023 • June 1, 2023
This review summarizes the research progress of stem cell transplantation for traumatic spinal cord injury (SCI) at different stages, based on the pathophysiological mechanisms of SCI. Clinical trials...
KEY FINDING: Clinical trials have demonstrated the safety and feasibility of stem cell transplantation in acute, subacute, and chronic SCI. These trials show potential for reducing inflammation and restoring nerve cell function.
Frontiers in Molecular Neuroscience, 2023 • June 5, 2023
The study aimed to determine the potential therapeutic mechanisms of pain by observing molecular expression in the ACC and PAG in the brain and animal behavior after local injection of human umbilical...
KEY FINDING: Local transplantation of HU-MSCs at the site of SCI partially relieves the neuropathic pain and promotes recovery of motor function.
Curr. Issues Mol. Biol., 2023 • June 16, 2023
Mesenchymal stromal cells are a type of adult cells that have shown great potential in treating various neurological disorders, including spinal cord injury. However, not only are MSCs themselves in t...
KEY FINDING: MSCs have the capacity to rapidly proliferate, where in a few weeks they can multiply their number several thousand times.
Journal of Advanced Research, 2024 • June 26, 2023
The study identifies a two-compound chemical cocktail (LC) capable of directly reprogramming cultured astrocytes into neuronal cells. LC successfully triggers neuronal reprogramming in the injured adu...
KEY FINDING: A combination of LDN193189 and CHIR99021 (LC) can reprogram cultured astrocytes into neuronal cells.
Clin Case Rep, 2023 • May 28, 2023
This case report presents the “first show phenomenon” observed after Regentime stem cell therapy in a spinal cord injury patient. The patient, who had complete motor and sensory loss due to a T9 injur...
KEY FINDING: The patient regained sensation to light touch in his lower limbs within the first week post-transplantation.
Regenerative Therapy, 2023 • June 7, 2023
This meta-analysis evaluates the therapeutic potential of stem cells from human exfoliated deciduous teeth (SHED) in preclinical animal models across various diseases. The study found statistically si...
KEY FINDING: SHED intervention in several diseases depicted statistically significant therapeutic effects in periodontitis, pulpitis, spinal cord injury, parkinson's disease, alzheimer's disease, focal cerebral ischemia, peripheral nerve injury, and retinal pigmentosa.