Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

Basic and Clinical Neuroscience, 2022 · DOI: http://dx.doi.org/10.32598/bcn.2021.1422.1 · Published: September 1, 2022

Spinal Cord Injury Regenerative Medicine Neurology

Simple Explanation

This review investigates the role of Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). A total of 34 preclinical studies were included. Our results showed that ChABC administration improves locomotion recovery after SCI. The findings of the present study showed that prescribing ChABC has a moderate effect in improving locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as adjuvant therapy and not as primary therapy.

Study Duration

Not specified

Participants

34 preclinical studies on rats and mice

Evidence Level

Systematic Review and Meta-analysis

Key Findings

1
ChABC administration improves locomotion recovery after SCI.
2
ChABC can improves locomotion recovery in all severity of SCI.
3
The treatment can improve locomotion in all follow-up duration.

Research Summary

The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating ChABC in improving the complications following SCI. The findings of the present study showed that prescribing ChABC has a moderate effect on the improvement of locomotion after SCI in rats and mice. The analyses showed that the efficacy of ChABC treatment is not affected by the differences in the SCI model, the severity of the injury, the number of administrations, the blinding status, the use of different locomotor scores, and the follow-up duration.

Practical Implications

Adjuvant Therapy

ChABC is more effective as an adjuvant therapy, used in combination with other treatments, rather than a primary therapy for spinal cord injuries.

Restoration of Neuronal Plasticity

ChABC's primary mechanism involves restoring neuronal plasticity in the spinal cord by digesting CSPGs and promoting axonal regeneration.

Combination Therapies

Future studies should focus on the effects of combining ChABC with other therapeutic approaches, such as stem cells or laser therapy, to enhance its effectiveness.

Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

Simple Explanation

Key Findings

Research Summary

Practical Implications

Adjuvant Therapy

Restoration of Neuronal Plasticity

Combination Therapies

Study Limitations

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Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

Simple Explanation

Key Findings

Research Summary

Practical Implications

Adjuvant Therapy

Restoration of Neuronal Plasticity

Combination Therapies

Study Limitations

Your Feedback

Was this summary helpful?