Regenerative Medicine Research

KEY FINDING: Expanded UCB cells are safe and feasible for treating haematological malignancies, showing greater engraftment potential than unexpanded UCB.

KEY FINDING: The study demonstrated a 50-fold expansion of skin-derived Schwann cells in a 500 mL bioreactor within one week.

KEY FINDING: Biomaterials can be designed to mimic the spinal cord's properties, promote neurogenesis, and improve the microenvironment for nerve regeneration after SCI.

KEY FINDING: Small EVs, particularly those derived from adipose tissue-MSCs (ADMSCs), offer therapeutic potential for improving neural structure after injury. They promote nerve regeneration and reduce risks associated with MSC transplantation, such as immune response and tumorigenesis.

KEY FINDING: FGF2 priming enhances the resistance of a subset of DPC clones to H2O2 cytotoxicity.

KEY FINDING: PTEN-KO using AAVrg’s improves locomotor outcomes in both acute and chronic SCI conditions, however, the effects are severity dependent.

KEY FINDING: Combined therapy with NSC transplantation and HIIT improved locomotor function with decreased maximum H to maximum M reflexes (H/M ratio) and increased the Basso–Beattie–Bresnahan score.

KEY FINDING: The study found that a specific method of preparing EVs, involving vortex mixing and filtration, resulted in more uniform and smaller vesicles.

KEY FINDING: The combination of nanoparticles and stem cells in animal models of SCI has a positive impact on neuroprotection and neuroregeneration.

KEY FINDING: Hydrogen significantly enhances BMSC proliferation, migration, and tolerance to serum deprivation in vitro.