Regenerative Medicine Research

KEY FINDING: Bexarotene reduces collagen deposition and the number of pathological neurons in the injured spinal cord.

KEY FINDING: Transplanted iNSCs survived for a short period but induced long-lasting changes in the microenvironment.

KEY FINDING: MSC-based therapies demonstrate improvements in AIS (ASIA Impairment Scale) grades, sensory scores, and, to a lesser extent, motor scores.

KEY FINDING: hUCMSC-derived exosomes notably alleviate spinal cord injury and cell apoptosis in a rat model.

KEY FINDING: miR-138-5p-modified UCMSC-Exos reduced inflammation in BV-2 cells by modulating the NLRP3-caspase1 signaling pathway.

KEY FINDING: ADSC sheet transplantation significantly improved voiding function recovery in rats after SCI and is therefore a promising cell delivery treatment option for NGB related to SCI.

KEY FINDING: H-EVs are more effective than EVs in promoting motor function recovery, anti-apoptosis, and anti-inflammatory effects after SCI, both in vivo and in vitro.

KEY FINDING: ZIF-8 promotes neural differentiation and angiogenesis of DPSCs by activating the JNK1/p38 MAPK signaling pathway through the continuous release of Zn2+.

KEY FINDING: ST2-CM increases neuronal activity in the dorsal horn (DH) of spinal cord organotypic cultures (SCOCs), as measured by Fos expression.

KEY FINDING: Neuronal transdifferentiation can be achieved mainly by ectopic overexpression of specific transcription factors (TFs). Key TFs like Ascl1, Brn2, and Myt1l can convert fibroblasts into functional neurons in vitro, which generate action potentials and form functional synapses. MicroRNAs (miRNAs) and small molecules, such as miR-9/9∗-124, can also induce neuronal transdifferentiation.