Regenerative Therapy, 2023 · DOI: https://doi.org/10.1016/j.reth.2023.06.004 · Published: June 7, 2023
Mesenchymal stem cells (MSCs) have great potential for self-renewal, differentiation, and immune modulation, making them useful in treating many diseases. Adult stem cells, including those from human exfoliated deciduous teeth (SHED), are a focus because of ethical concerns related to embryonic stem cells and the complexity of induced pluripotent stem cells. SHED, found in discarded baby teeth, share similarities with other MSCs but have higher proliferative potential. They are easily accessible, cost-effective, and can differentiate into various cell types, making them a promising source for regenerative medicine. This study systematically reviews and meta-analyzes the use of SHED in treating various diseases in animal models. The goal is to understand SHED's therapeutic capabilities and promote their use in regenerative medicine.
The data suggest that SHED therapy could be implemented in clinical trials pending further preclinical studies.
SHED could serve as a readily accessible and ethically less controversial source of stem cells for regenerative therapies.
The study supports the potential of SHED in targeted therapies for various diseases, including neurodegenerative disorders, liver fibrosis, and bone defects.