Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,081-2,090 of 2,298 results
Nature Communications, 2020 • December 22, 2020
The study introduces 'enriched conditioning,' a regenerative paradigm combining environmental enrichment (EE) and sciatic nerve axotomy (SNA) prior to spinal cord injury (SCI). Enriched conditioning s...
KEY FINDING: Combining environmental enrichment (EE) and sciatic nerve axotomy (SNA) before spinal cord injury (SCI) significantly enhances axon regeneration in dorsal root ganglia (DRG) sensory neurons.
Pharmaceutics, 2021 • December 26, 2020
This study aimed to develop lactoferrin-anchored tannylated mesoporous silica nanomaterials (LF/TA-MSNs) to enhance the osteo-differentiation ability of adipose-derived stem cells (ADSCs). The LF/TA-M...
KEY FINDING: LF/TA-MSNs demonstrated a prolonged release of lactoferrin (LF) for up to 28 days, indicating their potential for long-term drug delivery.
Clinical and Translational Medicine, 2020 • December 21, 2020
This study investigates the effect of extracellular vesicles derived from human stromal cells on the inner ear after noise trauma. The vesicles were characterized and tested in vitro in spiral ganglio...
KEY FINDING: Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) exerted immunomodulatory activity on T cells and microglial cells.
iScience, 2021 • January 22, 2021
This study uses genome-scale CRISPR screening in hPSCs to identify genes that prevent lineage specification, termed lineage-specification preventing genes (LPGs). The screening revealed that LPGs are ...
KEY FINDING: A genome-scale CRISPR screen in hPSCs identified lineage-specification preventing genes (LPGs) that, when knocked out, cause the cells to differentiate into specific germ layers.
Theranostics, 2021 • January 1, 2021
This study explores the potential of a regenerative complex composed of a collagen/silk fibroin scaffold and human umbilical cord mesenchymal stem cells (hUCMSCs) to treat traumatic brain injury (TBI)...
KEY FINDING: The collagen/SF scaffold exhibited favorable physical properties, suitable degradation rate, and biocompatibility.
PLoS ONE, 2021 • January 4, 2021
This systematic review analyzes the effects of ketogenic diets (KD) and intermittent fasting on nerve regeneration and repair following traumatic injuries to the spinal cord and peripheral nerves. The...
KEY FINDING: Intermittent fasting and the ketogenic diet may promote neuroprotection and facilitate the regeneration and repair of nerve fibers following injury.
Neurospine, 2020 • December 1, 2020
This review summarizes current knowledge on pharmacologic and regenerative cell therapies for spinal cord injury (SCI). It highlights the limitations of existing treatments and the need for further re...
KEY FINDING: Clinical studies of methylprednisolone for SCI have not shown clear benefits, and other drugs like Rho inhibitors and riluzole have also lacked significant positive outcomes.
Stem Cell Research & Therapy, 2021 • January 12, 2021
The study investigated the combined therapeutic potential of enteric neural stem cells (ENSCs) and chondroitinase ABC (ChABC) for spinal cord injury (SCI) repair in a rat contusion model. Results show...
KEY FINDING: The combined treatment of ENSCs and ChABC resulted in significant reductions in the injured tissue and cavity area compared to either treatment alone.
Stem Cell Research & Therapy, 2021 • January 25, 2021
This review discusses advances in combinatorial biomaterial scaffolds and MSC transplantation, targeting intercellular communications in the pathologic process following SCI. MSCs secrete various solu...
KEY FINDING: MSC transplantation promotes scaffold integration and regenerative growth potential, improving the healing process after SCI.
Prenatal Diagnosis, 2021 • January 1, 2021
This systematic review and meta-analysis evaluated the safety and efficacy of stem cell transplantation in animal models of MMC, finding beneficial effects on animal survival, defect coverage, and spi...
KEY FINDING: Intra-amniotic injection of allogeneic amniotic fluid mesenchymal stem cells (AF-MSCs) in the fetal rat model did not compromise fetal survival.