Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,091-2,100 of 2,298 results
Scientific Reports, 2021 • January 11, 2021
The study reveals that ascending DRG sensory neurons respond to SCI and alter their transcriptome differently than after SNI. SCI induces a stress response, marked by ATF3 and Jun upregulation, but th...
KEY FINDING: SCI induces a unique transcriptional response in DRG sensory neurons compared to peripheral nerve injury (SNI), with fewer differentially expressed genes and little overlap between conditions.
Cell Bioscience, 2021 • January 1, 2021
Several recent studies have been exploring the application of EVs in regenerative medicine. According to these studies, EVs have the potential of regulating immune microenvironment, promoting vascular...
KEY FINDING: EVs have essential roles in cell-to-cell interaction, organ-to-organ communication and also, can be introduced as a novel signaling mediator in whole-body communications.
NATURE COMMUNICATIONS, 2021 • January 13, 2021
This study demonstrates that transneuronal delivery of hyper-interleukin-6 (hIL-6) can promote significant locomotor recovery after a complete spinal cord crush in mice. The hIL-6 is delivered to cort...
KEY FINDING: Unilateral transduction of cortical motoneurons with AAV-hIL-6 resulted in significant locomotor recovery of both hindlimbs after complete spinal cord crush.
BMC Genomics, 2004 • August 13, 2004
The study developed expressed sequence tags (ESTs) for the Mexican axolotl (Ambystoma mexicanum) and the Eastern tiger salamander (A. tigrinum tigrinum) from various tissues, including regenerating li...
KEY FINDING: Approximately 40,000 cDNA sequences were isolated for A. mexicanum and A. t. tigrinum from various tissues.
Bio-protocol, 2019 • October 5, 2019
The study presents a novel protocol for creating a 3D decellularized scaffold from bovine spinal cord ECM (3D-dCBS) for neural tissue engineering. The method involves preparing a viscous ECM-derived g...
KEY FINDING: The protocol effectively removes approximately 94.47% of nuclear material from the native bovine spinal cord.
Ann Transl Med, 2020 • December 1, 2020
This study explores the therapeutic potential of extracellular vesicles (EVs) derived from skin precursor-derived Schwann cells (SKP-SCs) for promoting axonal regeneration in damaged motoneurons. The ...
KEY FINDING: SKP-SC-EVs can be internalized by neuronal cells both in vitro and in vivo, suggesting that they can deliver their cargo to the target cells.
Neural Plasticity, 2021 • January 6, 2021
This review summarizes the molecular mechanisms of the preconditioning injury effect on promoting axonal regeneration, focusing on injury signal transduction and RAG expression. The review highlights ...
KEY FINDING: Injury signal transduction resulting from preconditioning peripheral nerve injury regulates the RAG expression to enhance axonal regeneration.
World Journal of Stem Cells, 2020 • December 26, 2020
This study investigates the efficacy of rat embryonic stem cells (rESC) and autologous bone marrow-derived neurocytes (ABMDN) in promoting functional recovery after iatrogenic spinal cord injury (SCI)...
KEY FINDING: Both rESC and ABMDN groups showed significant improvement compared to the control group based on the BBB scale, indicating functional recovery after SCI.
Neural Development, 2021 • January 14, 2021
The study compares the cellular response to spinal cord injury in regenerative (R-stage) and non-regenerative (NR-stage) Xenopus laevis. R-stages exhibit rapid spinal cord restoration, activation of n...
KEY FINDING: Regenerative stages show rapid sealing of injured stumps, proliferation of cells lining the central canal, and formation of rosette-like structures.
Molecular Therapy: Methods & Clinical Development, 2021 • March 1, 2021
The study elucidates the role of the epigenetic regulatory network involving UTX/miR-24/NeuroD1 in axonal regeneration and functional recovery in mice following SCI. UTX is identified as an intrinsic ...
KEY FINDING: UTX expression is significantly increased post-SCI and represses axonal regeneration in vitro.