Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,071-2,080 of 2,298 results
Stem Cells International, 2020 • November 5, 2020
This review summarizes the research progress of SC therapy for SCI, including effects, strategies, related mechanisms, safety, and clinical application. Most studies support the effects of SC therapy ...
KEY FINDING: Stem cell therapy shows good effects for SCI treatment, with common SC types including MSCs, HSCs, NSCs, iPSCs, and ESCs.
Scientific Reports, 2020 • November 20, 2020
The study aimed to investigate if DCX+ NPCs can replace lost oligodendrocytes in the hippocampal DG after cuprizone-induced demyelination. The results showed a significant cuprizone-induced depletion ...
KEY FINDING: During remyelination, the number of GFP+ NPCs co-expressing Olig2 and CC1 significantly increased in the hippocampal DG.
Cells, 2020 • November 20, 2020
Neurodegenerative diseases and nervous system injuries have been a major focus of regenerative medicine, with many studies dedicated to developing efficient and clinically relevant hPSC replacement th...
KEY FINDING: hPSC-based therapies have shown potential for reversing motor defects in Parkinson's disease patients by replacing damaged dopamine neurons.
International Journal of Nanomedicine, 2020 • January 1, 2020
The study investigated the interaction between MSCs and CP in a rat stroke model, finding that MSCs migrate to the CP and enhance its proliferation. MRI reveals MSC migration towards the CP in an isch...
KEY FINDING: ION-labeled MSCs migrate to the CP in an ischemic stroke model, as revealed by MRI and histological analysis.
Nature Communications, 2020 • December 3, 2020
This study investigates whether repeated chemogenetic activation can enhance DRG axon regeneration following dorsal root crush, addressing both intrinsic and extrinsic limitations. The findings demons...
KEY FINDING: Chemogenetic activation of adult DRG neurons enhances neurite growth on CSPG spots in vitro, indicating that activation can help overcome inhibitory signals.
The Journal of Neuroscience, 2021 • January 20, 2021
This study identifies Myc as a transcriptional hub regulating regeneration-associated genes (RAGs) after preconditioning nerve injury. The research demonstrates that Myc binds to RAG promoters, and it...
KEY FINDING: Myc proto-oncogene functions as a transcriptional hub gene regulating a subset of regeneration-associated genes (RAGs) in DRGs following preconditioning injury.
Neuroscience Insights, 2020 • October 27, 2020
Injuries to the corticospinal tract following spinal cord injury leave patients with lifelong paralysis. We have demonstrated that corticospinal neurons activate intrinsic regenerative programs in res...
KEY FINDING: Injury to the CST induces significant changes in gene expression in corticospinal neurons, indicating the activation of intrinsic regenerative mechanisms.
Molecular Therapy: Nucleic Acids, 2020 • December 1, 2020
This study investigates the role of miR-135a-5p in promoting functional recovery after spinal cord injury (SCI) by targeting specific genes and downstream signaling pathways. The findings indicate tha...
KEY FINDING: MiR-135a-5p expression is significantly decreased after spinal cord injury in rats, suggesting a role in the injury response.
Biomedicines, 2020 • December 15, 2020
Cell therapy is gaining traction as a potential treatment for neurological diseases. Researchers are exploring the possibility of combining multiple types of cells to enhance therapeutic effects. This...
KEY FINDING: Combined cell therapy has shown successful application in treating neurological pathologies, including stroke, spinal cord injury, neurodegenerative diseases, Duchenne muscular dystrophy, and retinal degeneration, in both experimental and clinical studies.
International Journal of Molecular Sciences, 2020 • December 16, 2020
The findings suggest that NP-iPS demonstrate neuroprotective properties by regulating local gene expression and regulate plasticity by modulating the central nervous system (CNS) extracellular matrix s...
KEY FINDING: NP-iPS transplantation significantly preserved MNs, slowed disease progression, and extended the survival of all treated animals.