Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,041-2,050 of 2,298 results
Frontiers in Endocrinology, 2020 • July 17, 2020
This review highlights the potential of zebrafish as a model for personalized regenerative medicine, particularly in the context of endocrine diseases. Zebrafish possess remarkable regenerative capabi...
KEY FINDING: Zebrafish possess regenerative capabilities in various organs, making them suitable for studying regenerative medicine approaches for endocrine disorders like diabetes mellitus.
Stem Cells International, 2012 • August 28, 2012
The review highlights the limitations of current SCI treatments and the need for innovative approaches to facilitate neural regeneration and functional improvement. Combination therapies, incorporatin...
KEY FINDING: Combination therapies, involving neurotrophins and cell grafts, cotransplantation of different grafts, or anti-inhibitory therapies, show enhanced efficacy compared to individual treatments.
Stem Cells International, 2020 • June 17, 2020
This study aimed to identify a cost-effective combination of growth factors to improve NPC survival and differentiation in vitro and in vivo after spinal cord injury (SCI). A combination of EGF, bFGF,...
KEY FINDING: A growth factor cocktail (EGF, bFGF, and PDGF-AA) increased NPC proliferation and directed cell fate towards the oligodendroglial and neuronal lineage while reducing astrocytic differentiation in vitro.
Neural Regen Res, 2021 • January 1, 2021
This review provides a comprehensive assessment of Schwann cell (SC) function post-peripheral nerve injury (PNI), focusing on SC interactions with macrophages and fibroblasts, which significantly infl...
KEY FINDING: Schwann cells (SCs) recruit macrophages to the injury site through the expression of monocyte chemoattractant protein-1 and leukemia inhibitory factor, aiding in debris clearance following Wallerian degeneration.
PNAS, 2010 • June 22, 2010
This study investigated the effect of sialidase on recovery from spinal cord contusion injury in rats. Sialidase was delivered intrathecally to the injury site for two weeks, and motor behavior, auton...
KEY FINDING: Sialidase treatment significantly enhanced hindlimb motor function in rats with spinal cord contusion injuries, as measured by the BBB locomotor rating scale.
Neural Regen Res, 2021 • January 1, 2021
This study investigates the role of Krüppel-like factor-4 (Klf4) in axonal regeneration after nervous system damage in mammals. The researchers found that Klf4 knockout promotes peripheral nerve regen...
KEY FINDING: Klf4 expression in dorsal root ganglion sensory neurons was significantly reduced after peripheral axotomy, suggesting a link between sciatic nerve regeneration and Klf4.
Neural Regeneration Research, 2021 • January 1, 2021
This study investigates the effectiveness of a combined approach using laminin-coated filaments, Schwann cells, and glial cell line-derived neurotrophic factor (GDNF) to promote axonal regeneration in...
KEY FINDING: Channels with filaments significantly reduced the lesion cavity, astrocytic gliosis, and inflammatory responses at the graft-host boundaries.
Neural Regen Res, 2021 • August 24, 2020
This retrospective case series evaluated the safety and effectiveness of combined autologous PRP and BMAC administration via intrathecal and intravenous routes in seven SCI patients. The study found t...
KEY FINDING: Intrathecal/intravenous co-administration of PRP and BMAC resulted in no significant complications.
Cells, 2020 • August 29, 2020
Peripheral nerve injuries (PNI) affect approximately 1 million people worldwide annually, and long-gap nerve injuries present significant clinical challenges, often requiring autologous nerve transpla...
KEY FINDING: Schwann cell transplantation can help overcome hurdles and reverse the inhibitory microenvironment into a permissive niche for regeneration.
ENEURO, 2020 • September 4, 2020
TGFb 1 mRNA is upregulated in the stroke-affected CST and iGM in the cervical spinal cord after a large stroke to the motor cortex, when compensatory axonal sprouting may be triggered. In vitro neurit...
KEY FINDING: TGFb 1 rescues neurite outgrowth under growth inhibitory conditions via the canonical TGFb R2/ALK5 signaling axis.