Neural Regen Res, 2021 · DOI: https://doi.org/10.4103/1673-5374.286978 · Published: January 1, 2021
This study investigates the role of Krüppel-like factor-4 (Klf4) in axonal regeneration after nervous system damage in mammals. Prior research suggests Klf4 deletion promotes axonal regeneration in retinal ganglion cells. The researchers used a mouse model of sciatic nerve injury and found that Klf4 expression decreased in dorsal root ganglion sensory neurons after injury, suggesting a link between sciatic nerve regeneration and Klf4. They further demonstrated that Klf4 knockout enhances axonal regeneration in vitro and in vivo. The study also showed that deleting Klf4 in the cortex of mice with spinal cord injury enhanced corticospinal tract regeneration. These findings indicate that regulating Klf4 activity could be a potential strategy for promoting axonal regeneration and functional recovery after nervous system injury.
Regulating KLF4 activity in neurons is a potential strategy for promoting axonal regeneration and functional recovery after nervous system injury.
The findings contribute to a better understanding of the molecular mechanisms involved in nerve regeneration and could lead to the development of new therapies for nerve injuries.
Further study is needed to more fully elucidate the role of KLF4 in neural regeneration, including its effects on motor neurons and the molecular mechanisms involved.