Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,051-2,060 of 2,298 results
Proc. R. Soc. B, 2020 • August 26, 2020
The study demonstrates that the West African lungfish exhibits salamander-like tail regeneration, characterized by blastema formation and restoration of original tail structures. The process involves ...
KEY FINDING: Lungfish tail regeneration closely resembles that of salamanders, involving the formation of a blastema and restoration of original tail structures, including muscle, skeleton, and spinal cord.
Cell Metab, 2020 • November 3, 2020
The study investigates the inhibitory environment of the mature CNS, demonstrating its reversibility through glial metabolic reprogramming. Increased glycolysis in glia, mediated by L-lactate and L-2H...
KEY FINDING: Activation of PI3K and EGFR pathways in glial cells significantly enhances axon regeneration in the CNS of Drosophila.
Biomolecules, 2020 • September 15, 2020
MSC-derived exosomes can specifically target and accumulate in brain lesion sites in various murine models of diseases, where they improve the behavioral phenotype as well as reducing the inflammatory...
KEY FINDING: MSC-derived exosomes have shown therapeutic promise in various neurodegenerative disease models, leading to improvement in functional outcomes in stroke, MS, and SCI.
Cells, 2020 • September 17, 2020
This review highlights recent findings on the applications of HA-based materials in CNS regenerative medicine, emphasizing its impact on cell signaling and customizable properties. HA plays a signific...
KEY FINDING: HA influences cell migration, proliferation, differentiation, and other cell behaviors, playing a significant role in maintaining homeostasis in neuronal tissue.
Neural Regeneration Research, 2021 • September 22, 2020
This review discusses the potential of targeting Epac2, a downstream effector of cAMP, as a therapeutic strategy for traumatic spinal cord injury (TSCI). Epac2 is mainly expressed postnatally in the C...
KEY FINDING: Epac2 activation can modulate the post-lesion environment following traumatic spinal cord injury, decreasing the activation of astrocytes and microglia.
Neural Regen Res, 2021 • September 22, 2020
This study investigated the effects of a new epidural electrical stimulation (EES) model on restoring motor ability in a rat model of complete spinal cord injury (SCI). The designed flexible electrode...
KEY FINDING: The flexible extradural electrode exhibited good anatomical topology and matched the spinal canal shape, allowing precise stimulation of the L2–3 and S1 spinal cord segments.
Neurotherapeutics, 2021 • September 30, 2020
This study assesses the effects of GSK-3 inhibition on neurogenesis both in vitro and in vivo following spinal cord injury (SCI). Herein, we assessed the effects of GSK-3 inhibition in vitro on the ne...
KEY FINDING: Ro3303544 activates β-catenin signaling and increases the expression of the bIII-tubulin neuronal marker in vitro. We report that the treatment of epSPCs and human pluripotent stem cell–derived neural progenitors (hPSC-NPs) with the GSK-3 inhibitor Ro3303544 activates β-catenin signaling and increases the expression of the bIII-tubulin neuronal marker
Polymers, 2020 • September 29, 2020
This study developed a collagen scaffold for glial scar replacement in a rat model of SCI, aiming to enhance axonal regeneration and neural plasticity. The collagen scaffold demonstrated excellent bio...
KEY FINDING: The collagen scaffold implantation promoted neuronal survival and axonal growth within the injured site and prevented glial scar formation by controlling astrocyte production for their normal functioning.
Front. Cell Dev. Biol., 2020 • August 18, 2020
Neural injury in mammals often leads to persistent functional deficits as spontaneous repair in the peripheral nervous system (PNS) is often incomplete, while endogenous repair mechanisms in the centra...
KEY FINDING: Electrical stimulation of peripheral nerves elicits a retrograde calcium signal, which can be visualized in vivo using genetically encoded calcium indicators.
Nature, 2020 • November 1, 2020
This study investigates spinal cord injury repair in neonatal mice, revealing scar-free healing and axon regeneration, unlike the scar formation observed in adult mammals. Microglia play a crucial rol...
KEY FINDING: Neonatal mice exhibit scar-free healing and long projecting axon growth after spinal cord crush injury, unlike adult mice which form scars.