Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,031-2,040 of 2,298 results
Neural Regen Res, 2020 • June 19, 2020
This study compares the effectiveness of human umbilical cord-derived mesenchymal stem cells (UCMSCs) and human adipose tissue-derived mesenchymal stem cells (ADMSCs) in treating spinal cord injury (S...
KEY FINDING: Transplanted UCMSCs and ADMSCs similarly improved motor and sensory function after spinal cord injury in rats.
Curr Opin Genet Dev, 2020 • October 1, 2020
The spiny mouse (Acomys) exhibits exceptional regenerative abilities in various tissues and organs compared to typical mammals. Regeneration in Acomys is associated with a blunted inflammatory respons...
KEY FINDING: Acomys can regenerate skin, including hair follicles, sebaceous glands, dermis, and muscle, without forming scars after excisional wounds or burns.
Scientific Reports, 2020 • July 15, 2020
This study demonstrates that Schwann cells transduced with lentiviral vectors encoding ChABC can constitutively secrete high quantities of active mChABC, leading to CS-GAG removal and altered cell beh...
KEY FINDING: mChABC robustly secreted from transduced Schwann cells leads to large-scale CSPG digestion, facilitating migration and adhesion on inhibitory substrates.
ACS Omega, 2020 • June 25, 2020
This study investigated the anti-inflammatory effects of bFGF and DPSCs, delivered via a thermosensitive hydrogel, in a rat model of spinal cord injury. The results showed that the combined use of bFG...
KEY FINDING: bFGF and DPSCs together effectively attenuate tissue inflammation in the injured spinal cord, leading to better nerve repair.
STEM CELLS Transl Med, 2020 • September 1, 2020
This review summarizes the most promising preclinical and clinical cell approaches to date including transplantation of mesenchymal stem cells, neural stem cells, oligodendrocyte progenitor cells, Sch...
KEY FINDING: Cell-based therapies, including mesenchymal stem cells (MSCs), neural stem cells (NSCs), oligodendrocyte progenitor cells (OPCs), Schwann cells (SCs), and olfactory ensheathing cells (OECs), show promise in promoting neuroprotection and neuroregeneration after SCI.
J Comp Neurol, 2021 • January 1, 2021
This study used RNA sequencing to examine gene expression profiles in regenerating and nonregenerating spinal cords of opossums after injury at different ages. The study demonstrated a more complex an...
KEY FINDING: The study identified 558 genes whose expression changed after spinal cord injury, with most being upregulated.
Frontiers in Endocrinology, 2020 • July 3, 2020
Osteoporosis, a chronic skeletal disorder common in older adults, leads to fractures due to decreased bone mass. Current treatments are insufficient, making stem cell therapies a promising regenerativ...
KEY FINDING: Mesenchymal stem cells (MSCs) are pivotal candidates for bone regeneration due to their anti-inflammatory and immune-privileged potential, making them ethically less concerning than other stem cell types.
International Journal of Molecular Sciences, 2020 • July 30, 2020
This study investigates the effects of Nogo-A antibodies on neuronal survival and neurite outgrowth, focusing on the direct interaction of these antibodies with Nogo-A expressed in neurons. The result...
KEY FINDING: Nogo-A antibodies (both monoclonal and polyclonal) enhance neurite outgrowth in cultured cerebellar granule neurons.
Biomedicines, 2020 • July 31, 2020
This study explores the potential of combined fasudil and menthol treatment to enhance recovery from spinal cord injury (SCI) in rats. The results indicate that the combined treatment significantly im...
KEY FINDING: Combined treatment with fasudil and menthol significantly improved locomotor function in rats with SCI, as indicated by higher BBB scores compared to single treatments or the injury-alone group.
BMC Genomics, 2020 • August 6, 2020
This study identifies deep, phylogenetically conserved commonalities between CNS axon regeneration and other examples of successful tissue regeneration and provides new targets for studying the molecu...
KEY FINDING: A set of 324 genes ("DESR genes") were differentially expressed in regenerative CNS regions (optic nerve and tadpole spinal cord) but not in non-regenerative regions.