Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,991-2,000 of 2,298 results
International Journal of Nanomedicine, 2020 • January 27, 2020
The study explores the impact of graphene oxide nanoparticle (GO NP) size on mouse neural stem cell (mNSC) fate, including self-renewal and differentiation. Results showed that GO NPs generally exhibi...
KEY FINDING: GO NPs of all sizes showed low cytotoxicity at a concentration of 20 μg/mL on the mNSCs.
Neural Regeneration Research, 2020 • February 28, 2020
SCI-induced neurological disability is predominantly attributed to failure of axons to regenerate in a spinal cord lesion. Recent studies have demonstrated that epigenetic regulations play pivotal rol...
KEY FINDING: Histone modifications, such as acetylation and methylation, significantly influence axon regeneration by modulating the expression of regeneration-associated genes (RAGs).
Neural Regen Res, 2020 • February 28, 2020
This study investigates the potential of collagen scaffolds combined with human umbilical cord-mesenchymal stem cells (hUC-MSCs) to promote functional recovery after acute complete spinal cord injury ...
KEY FINDING: Transplantation of hUC-MSCs on collagen scaffolds resulted in increased motor scores in animal models.
Brain, 2020 • May 6, 2020
This study investigated the safety and efficacy of NgR1-Fc (AXER-204), a Nogo receptor decoy, in treating spinal cord injury in non-human primates. The results indicated that NgR1-Fc is safe for admin...
KEY FINDING: NgR1-Fc (AXER-204) administration showed no preclinical toxicological issues in healthy animals or safety concerns in spinal cord injury animals.
Cureus, 2020 • February 16, 2020
This study investigates gene expression modulation during spinal cord regeneration in the axolotl model using next-generation sequencing. The research identified differentially expressed genes and enr...
KEY FINDING: The data revealed 363 genes differentially expressed between zero and seven days post-amputation, mostly downregulated.
Cells, 2020 • March 27, 2020
The study investigates the effect of NeuroHeal, a combination of Acamprosate and Ribavirin, on sensory fiber regeneration and neuropathic pain in rat models of peripheral nerve injury. The treatment a...
KEY FINDING: NeuroHeal treatment reduced signs of neuropathic pain in rat models of spare nerve injury and nerve crush.
Cell Transplantation, 2020 • January 3, 2020
This study developed a technological platform for transplanting cells into the spinal cord injury (SCI) site of adult zebrafish and determined that transplanting 300 GFP(+) cells is the optimal number...
KEY FINDING: Transplanting 300 GFP(+) cells into adult zebrafish with SCI resulted in the highest survival rate compared to transplanting 100, 500, or 1,000 cells.
Soft Matter, 2020 • April 15, 2020
This study presents the synthesis of peptide-functionalized polymers containing a peptide sequence for incorporation into self-assembled peptide hydrogels, along with bioactive peptides that inhibit s...
KEY FINDING: Peptide-functionalized polymers can be integrated into self-assembled peptide hydrogels while maintaining similar mechanical properties (soft and shear-thinning) to peptide-only hydrogels.
Neural Regen Res, 2020 • May 1, 2020
This corrigendum addresses an error in the author affiliations of a previously published article in Neural Regeneration Research. The original article focused on a novel approach to promote nerve rege...
KEY FINDING: The corrigendum rectifies incorrect author affiliations in the original publication.
Cell Transplantation, 2020 • January 1, 2020
This study investigates the therapeutic potential of transplanting olfactory ensheathing cells (OECs) modified to silence miR-199a-5p in rats with spinal cord injury (SCI). The researchers hypothesize...
KEY FINDING: Spinal cord injury significantly increased miR-199a-5p levels, while OEC transplants significantly reduced its expression.