Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,981-1,990 of 2,298 results
STEM CELLS TRANSLATIONAL MEDICINE, 2020 • May 1, 2020
This study investigates the pathophysiology of spinal cord injury (SCI) in a rat model, revealing unevenly distributed hypoxic areas within the injured spinal cord. It introduces a novel therapeutic a...
KEY FINDING: Hypoxia was unevenly interspersed in compressed spinal cord injury (SCI) in a rat model.
Adv Funct Mater, 2020 • January 3, 2020
3D printing offers a promising approach to neural regeneration by enabling the creation of patient-specific scaffolds with precise control over geometry, mechanics, and biology. The development of 3D ...
KEY FINDING: 3D printing offers vital features such as coupling with 3D imaging, robotics-based biomanufacturing, compatibility with multiple material sets, and rapid prototyping.
The Journal of Neuroscience, 2020 • March 25, 2020
This study investigates the function of Yes-associated protein (YAP) in the formation of glial scars after spinal cord injury (SCI) through regulation of astrocyte proliferation. YAP promotes the prol...
KEY FINDING: YAP was upregulated and activated in astrocytes of C57BL/6 male mice after SCI in a Hippo pathway-dependent manner.
Pharmaceuticals, 2020 • February 20, 2020
Cell secretome-based therapies are emerging as a promising approach for treating CNS disorders, offering potential advantages over traditional cell transplantation methods. The secretome's paracrine e...
KEY FINDING: MSC-based therapies, particularly those utilizing the cell secretome, show promise in treating CNS diseases like SCI, TBI, IS, and PD. The secretome's regenerative effects are attributed to secreted factors and vesicles rather than cellular differentiation.
Cell Metab, 2020 • March 3, 2020
Axonal regeneration in the central nervous system (CNS) is a highly energy demanding process. Extrinsic insults and intrinsic restrictions lead to an energy crisis in injured axons, raising the questi...
KEY FINDING: Enhancing axonal mitochondrial transport via genetic Snph deletion in mice recovered injury-induced mitochondrial damage.
Frontiers in Neurology, 2020 • March 10, 2020
The study evaluated single and combined treatments—pre-degenerated peripheral nerve grafts (PPN), bone marrow stromal cells (BMSCs), and chondroitinase ABC (ChABC)—on rats with chronic spinal cord inj...
KEY FINDING: Combined treatment groups (PPN + BMSCs and PPN + BMSCs + ChABC) showed significant axonal regrowth, indicated by increased GAP-43 and MAP-1B expression in axonal fibers.
EBioMedicine, 2020 • January 1, 2020
The study aimed to investigate the regenerative effects of transplanting bone marrow-derived mesenchymal stem cells (BMSCs) embedded in ultra-purified alginate (UPAL) gel on degenerated intervertebral ...
KEY FINDING: Co-culturing nucleus pulposus cells (NPCs) and bone marrow-derived mesenchymal stem cells (BMSCs) in UPAL gel significantly increased the expression of NPC markers, growth factors, and extracellular matrix genes compared to monocultures.
Exp Neurol, 2020 • June 1, 2020
The review focuses on the role of chondroitin sulfate proteoglycans (CSPGs) and their interaction with the receptor protein tyrosine phosphatase sigma (PTPσ) in regulating autophagy following spinal c...
KEY FINDING: CSPGs, particularly those with CS-E sulfation, bind with high affinity to PTPσ on axonal growth cones, disrupting autophagic flux by preventing autophagosome-lysosome fusion.
PLoS ONE, 2020 • March 10, 2020
This study investigates the effects of human mesenchymal stem/stromal cells (hMSCs) on spinal cord injury (SCI) recovery in mice, focusing on the roles of chemokines CCL2/CCR2 and CCL5/CCR5. The resea...
KEY FINDING: hMSC transplantation enhanced Ccl2 and Ccl5 expression and improved locomotor activity in mice with SCI.
Cellular and Molecular Neurobiology, 2020 • March 14, 2020
Here, we developed a tissue culture model for CST regeneration and found that IL-4 promoted new growth cone formation after axon transection. Most importantly, IL-4 directly increased the regenerative...
KEY FINDING: IL-4 promoted new growth cone formation after axon transection.