Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,001-2,010 of 2,298 results
Front. Cell. Neurosci., 2020 • March 19, 2020
This study investigated the role of PTPσ in axon regeneration after spinal cord injury (SCI) in lampreys, which can recover from complete spinal cord transection. Using antisense morpholino oligomers ...
KEY FINDING: Knocking down PTPσ expression significantly impaired reticulospinal axon regeneration in lampreys, primarily due to reduced long-term neuron survival.
Front. Cell Dev. Biol., 2020 • March 20, 2020
The study investigates the effects of inhibiting gamma-secretase on axon regeneration after spinal cord injury in lampreys. RNA-Seq analysis revealed downregulation of a HES transcription factor (HESB...
KEY FINDING: Gamma-secretase inhibition reduces HESB expression in the brainstem of spinal cord injured lampreys.
Bioengineering, 2020 • April 12, 2020
This study investigated the impact of dual cell co-culture and cell-conditioned media on the yield and function of human olfactory cell lines for regenerative medicine. The research found that conditi...
KEY FINDING: Rat OECs cultured on fibroblast feeders had greater expression of p75NTR compared to those cultured on laminin.
Regenerative Biomaterials, 2020 • January 1, 2020
The study successfully fabricated SC-NSC core–shell fibers using a coaxial nozzle, encapsulating SCs in an alginate hydrogel shell and NSCs in the core. SCs in the shell exhibited higher expression of...
KEY FINDING: Schwann cells (SCs) encapsulated in the alginate hydrogel shell expressed more genes of neurotrophic factors compared to those cultured in petri dishes, indicating enhanced neurotrophic support.
Frontiers in Neurology, 2020 • April 2, 2020
This study evaluated the efficacy of a combination therapy (scar removal, INDP, and fibrin glue matrix with MSCs) compared to INDP alone in rats with chronic spinal cord injury. The combination therap...
KEY FINDING: INDP alone significantly increased motor recovery in rats with chronic SCI compared to the combination therapy and control groups.
PRS Global Open, 2020 • February 11, 2020
This study investigated the use of gelatin hydrogel conduits containing fetal neocortex or spinal cord tissue to promote peripheral nerve regeneration after injury in mice. The results showed that the...
KEY FINDING: The gelatin hydrogel conduit is suitable for nerve re-growth after injury.
eLife, 2020 • April 27, 2020
By intersecting chromatin accessibility data with single-cell transcriptomics, we find that NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to prol...
KEY FINDING: NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to proliferation.
Molecular Therapy, 2020 • August 1, 2020
This study demonstrates the novel function of Lin28 in controlling regrowth of motor and sensory neurons in adult mammalian CNS. Upregulating Lin28a stimulated dramatic and long distance regeneration ...
KEY FINDING: Upregulation of Lin28a in transgenic mice induces significant long-distance regeneration of corticospinal axons and the optic nerve in adult mice.
Brain Res, 2020 • August 1, 2020
Axonal injury in the PNS invokes axon-to-soma and axon-to-nucleus signals through back-propagating wave of Ca2+ and retrograde transport of signaling proteins that change gene expression to support re...
KEY FINDING: Increased axoplasmic calcium is an early response to initiate regenerative growth programs, but excessive levels can trigger axon degeneration.
International Journal of Molecular Sciences, 2020 • May 4, 2020
Neurodegenerative disorders (NDs) are a growing problem worldwide, and current treatments are limited to addressing symptoms rather than underlying mechanisms. Biomaterials offer a promising therapeut...
KEY FINDING: Hydrogels serve as effective scaffolds for stem cell culture and differentiation, while also acting as carriers for growth factors that support cell growth.