Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,831-1,840 of 2,298 results
Stem Cell Reports, 2018 • December 11, 2018
The study evaluated the efficacy of GSI-treated hiPSC-NS/PC transplantation in treating chronic SCI. The treatment resulted in significantly enhanced axonal regrowth, remyelination, inhibitory synapse...
KEY FINDING: GSI-treated hiPSC-NS/PCs led to enhanced axonal regrowth and remyelination in chronically injured spinal cords.
Frontiers in Neuroscience, 2018 • November 13, 2018
This study compares gene expression patterns in rats and axolotls after spinal cord injury to understand the differences between regeneration and scarring mechanisms. The researchers performed a four-...
KEY FINDING: Extracellular matrix genes were upregulated in both rats and axolotls after spinal cord injury at all time points (days 1, 3, and 7), indicating the importance of extracellular matrix remodeling in wound healing.
Regenerative Therapy, 2018 • October 3, 2018
Magnetic targeting is a cell delivery system that utilizes magnetic labeling of cells and a magnetic field to achieve minimally invasive cell transplantation. The technique has shown promise in animal...
KEY FINDING: Magnetic targeting enhances the infiltration of MSCs into artificial bone and bone formation in rabbit forelimb bone defect model.
Neural Regen Res, 2019 • January 1, 2019
Spinal cord injury (SCI) lacks effective treatments, necessitating regenerative strategies. Tissue engineering offers promise but faces challenges such as limited self-regeneration in the CNS. Combina...
KEY FINDING: Collagen matrices can support the growth of neurites and blood vessels in the injured spinal cord.
Neural Regen Res, 2019 • March 1, 2019
This study investigates the role of ferroptosis, an iron-dependent cell death pathway, in secondary injury following spinal cord injury (SCI) and the potential therapeutic effect of deferoxamine (DFO)...
KEY FINDING: Deferoxamine (DFO) treatment improved hindlimb locomotor function in rats with spinal cord injury (SCI).
Glia, 2019 • March 1, 2019
Intraspinal transplantation of astrocyte progenitors in the C2 hemisection model of SCI promoted: (a) significant recovery of diaphragmatic respiratory function, (b) robust regeneration of damaged bul...
KEY FINDING: GRP transplantation promoted significant recovery of diaphragm electromyography amplitudes, demonstrating substantial recovery of diaphragm function.
eNeuro, 2018 • October 22, 2018
The study evaluated the therapeutic benefits of LOTUS pan-neuronal overexpression in the injured spinal cord using a clinically relevant contusive SCI model. LOTUS has a neuroprotective effect on the ...
KEY FINDING: LOTUS overexpression reduced spinal cord atrophy and protected myelinated neuronal fibers against injury.
Adv Mater, 2019 • January 1, 2019
Advances in biomaterial synthesis, stem cell biology, bioimaging, microsurgery, and microscale technologies have made minimally invasive therapeutics a viable tool in regenerative medicine. Therapeuti...
KEY FINDING: Needles have been utilized to deliver cell-laden biomaterials into the body.
Dev Dyn, 2019 • February 1, 2019
This study demonstrates that reactive oxygen species (ROS) are required for tail regeneration in axolotl embryos. ROS levels increase rapidly after amputation and remain elevated for the first 24 hour...
KEY FINDING: ROS levels increase rapidly following tail amputation in axolotl embryos, peaking within minutes and remaining elevated for 24 hours.
Journal of Clinical Medicine, 2019 • December 25, 2018
This study investigates the potential of conditioned medium from mesenchymal stem cells (MSCcm) as a cell-free therapy for spinal cord injury (SCI). The results demonstrate that MSCcm promotes neurona...
KEY FINDING: MSC coculture extensively induced neurite outgrowth in cortical neuron–glial cultures.