Neural Regen Res, 2019 · DOI: 10.4103/1673-5374.243705 · Published: January 1, 2019
Spinal cord injury (SCI) leads to loss of motor and sensory function and other complications. Current treatments are lacking, so strategies to promote neuronal regeneration are crucial. Tissue engineering offers promise through biocompatible scaffolds that support tissue regrowth. These scaffolds can be combined with growth factors or cells to enhance regeneration. Future therapies may combine biomaterials, cell therapies, and drugs to address secondary injury events and promote organized neuronal plasticity, along with rehabilitation techniques.
Focus on developing biocompatible and biodegradable scaffolds that can serve as vehicles for cell and drug delivery.
Integrate biomaterials with cells, drugs targeting secondary injury events, and neurotrophic factors to enhance regeneration.
Combine tissue engineering with epidural stimulation, brain-machine interfaces, and neurorehabilitation for comprehensive SCI treatment.