Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,821-1,830 of 2,298 results
Journal of Orthopaedic Surgery and Research, 2018 • September 28, 2018
This study explored the use of serum chemokine analysis to predict outcomes in non-union patients undergoing Masquelet therapy. The research identified CCL-3 and IFN-γ as potential biomarkers that, wh...
KEY FINDING: CCL-3 expression was significantly higher in non-responders (NR) compared to responders (R) during the study course (p = 0.002).
Regen. Med., 2018 • October 22, 2018
The study aimed to determine the bone regenerative potential of a cellular allograft uniquely processed from UCB to optimize high MNC count and to enrich cytokine content. The UCBp-CM elevated prolife...
KEY FINDING: UCBp-CM elevated proliferation and migration rates of mesenchymal stem cells (MSCs) and bone marrow stromal cells.
PLoS ONE, 2018 • October 26, 2018
This study presents a mathematical model characterizing regenerative axons growing along a multifunctional scaffold after spinal cord injury (SCI). The model focuses on the effects of scaffold archite...
KEY FINDING: A slimmer scaffold with a small on-ramp slope improves the success rate of axonal regeneration.
J Neurosci Res, 2019 • February 1, 2019
Transplantation of neural progenitor cells has a history of use for repair of the injured central nervous system and has shown some efficacy in promoting repair and functional recovery following exper...
KEY FINDING: Transplanted tissue can produce a heterogeneous mix of mature neurons and glia and become vascularized.
Nature Communications, 2018 • November 6, 2018
The study demonstrates that spinal cord injury leads to an inflammatory response that promotes axonal regeneration. Inhibiting inflammation reduces the number of immune cells and impairs axonal bridgi...
KEY FINDING: Inhibiting inflammation reduces and promoting inflammation accelerates axonal regeneration in spinal-lesioned zebrafish larvae.
International Journal of Stem Cells, 2018 • October 31, 2018
This study investigated the effects of transplanting human mesenchymal stem cells (hMSCs) genetically modified to express Olig2 in a rat model of spinal cord injury (SCI). The results showed that tran...
KEY FINDING: Transplantation of Olig2-expressing hMSCs significantly improved functional recovery in a rat model of contusive SCI compared to the control hMSC-transplanted group.
Frontiers in Bioengineering and Biotechnology, 2018 • November 1, 2018
The study focuses on developing a tissue-specific neuronal construct using human neural precursor cells (hNPCs) on decellularized meningeal scaffolds (DMS) to support the structural and functional asp...
KEY FINDING: Decellularized meningeal scaffolds (DMS) maintain a 3D architecture and extracellular matrix (ECM), promoting long-term survival and function of neurological cells.
Neural Development, 2018 • November 8, 2018
This study examines the roles of different Fgf members and their receptors in neurogenesis and regeneration following spinal cord injury (SCI) in zebrafish, comparing these roles to those during devel...
KEY FINDING: Fgf3 drives neurogenesis of Islet1 expressing motor neuron subtypes and mediate axonogenesis in cMet expressing motor neuron subtypes.
Stem Cell Reports, 2018 • November 13, 2018
The study focuses on engineering lineage-tracing systems in human embryonic stem cells (hESCs) using genetic recombination techniques. The goal is to specify human developmental principles using an a...
KEY FINDING: The AAVS1 locus in human cells is suitable for integrating conditional reporters for reliable transgene expression during lineage tracing.
Asian Journal of Neurosurgery, 2018 • October 1, 2018
This study investigates the effects of spinal cord-derived neural precursor cells (NPCs) transplantation on SCI in after and before injury injection. Our results indicate that NPCs infusion both pre‑ ...
KEY FINDING: NPCs infusion both before and after SCI could decrease the level of inflammatory cytokines, indicating a modulatory effect on inflammation.