Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,841-1,850 of 2,298 results
Tissue Eng Regen Med, 2016 • October 1, 2016
The study investigated the impact of olfactory ensheathing cell (OEC)-seeded collagen scaffolds on spinal cord injury repair in rats, focusing on axon regeneration and functional recovery. While OEC-s...
KEY FINDING: OEC-seeded scaffolds showed a trend towards improved integration and nerve regeneration, but it wasn't statistically significant.
Tissue Eng Regen Med, 2016 • June 1, 2016
This study demonstrates that VEGF enhances axonal outgrowth in organotypic spinal cord slices through VEGFR1 and VEGFR2. The neurotrophic function of VEGF is mediated by the consequent triggering of t...
KEY FINDING: Exogenous VEGF significantly promoted axonal outgrowth and upregulated VEGFR1 and VEGFR2 in organotypic spinal cord cultures.
Molecular Therapy, 2019 • February 1, 2019
This study introduces a scaffold-mediated approach for the sustained, non-viral delivery of miR-219/miR-338 to promote CNS remyelination. The aligned fiber-hydrogel scaffold was used to deliver miR-21...
KEY FINDING: miR-219/miR-338 treatment significantly enhanced OPC differentiation and maturation, leading to a greater number of mature, myelin basic protein-positive OLs compared to controls.
Journal of Biomedical Science, 2020 • March 26, 2020
The study evaluated the therapeutic potential of human bone marrow-derived stromal cells (bmSC) prepared by negative selection in a rat model of spinal cord injury (SCI). Compared to methylprednisolon...
KEY FINDING: Rats treated with bmSC showed improved motor function compared to those treated with methylprednisolone (MP) following spinal cord injury.
Neural Regeneration Research, 2019 • April 1, 2019
This study evaluated the therapeutic potential of Qian-Zheng-San (QZS) on sciatic nerve crush injury in rats. Results indicated that QZS promoted nerve regeneration, improved nerve function, and enhan...
KEY FINDING: Qian-Zheng-San (QZS) treatment resulted in a higher sciatic nerve function index (SFI) in rats at 2 and 4 weeks post-surgery compared to the control group, indicating improved motor function.
Neural Regen Res, 2019 • April 1, 2019
This study investigated the effectiveness of different nerve transposition techniques in repairing long-segment ulnar nerve defects in rats. The musculocutaneous nerve, medial pectoral nerve, muscular...
KEY FINDING: Repairing a long ulnar nerve defect with different donor nerve transpositions can restore axonal function.
Neural Regen Res, 2019 • April 1, 2019
The study aimed to observe the effect of nerve regeneration and motor function recovery after several types of nerve transposition for median nerve defect. Results showed that wrist flexion function w...
KEY FINDING: Wrist flexion function was restored in all three nerve transposition groups and the epineurial neurorrhaphy group.
Glia, 2019 • May 1, 2019
The study investigates the role of Nrg1/ErbB signaling in mediating spontaneous regenerative processes and functional repair after spinal cord injury (SCI). Conditional ablation of ErbB receptors in c...
KEY FINDING: Ablation of ErbB receptors in PDGFRα-expressing cells led to a dramatic reduction in P0-positive remyelination in the dorsal columns following spinal contusion injury.
Nat Med, 2019 • February 1, 2019
This study demonstrates the use of rapid 3D printing to create biomimetic central nervous system structures that can be individualized and scaled to patient-specific lesion shapes and lengths. The sca...
KEY FINDING: Injured host axons regenerate into 3D biomimetic scaffolds and synapse onto NPCs implanted into the device.
Nat Neurosci, 2019 • February 1, 2019
The study identifies RNAs regulated by TDP-43 in human motor neurons, revealing that STMN2 expression declines after TDP-43 knockdown and mislocalization. It demonstrates that STMN2 is essential for a...
KEY FINDING: TDP-43 knockdown in human motor neurons (hMNs) leads to decreased STMN2 expression due to altered splicing.