Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,741-1,750 of 2,298 results
Frontiers in Pharmacology, 2018 • April 10, 2018
This study evaluated the effectiveness of adipose-derived mesenchymal stem cells (AD-MSCs) combined with a fibrin matrix in promoting structural and functional recovery following spinal cord injury (S...
KEY FINDING: The application of AD-MSCs combined with fibrin matrix significantly improved motor function in rats with SCI, as demonstrated by higher BBB locomotor scores compared to the control group.
Nat Med, 2018 • May 1, 2018
This study investigated the potential of human neural stem cell grafts to restore function after spinal cord injury in rhesus monkeys. The results showed that the grafts survived, matured, and integra...
KEY FINDING: Human neural stem cells can be successfully engrafted to fill the large lesion cavity of a non-human primate spinal cord.
Neurosurgery, 2019 • January 1, 2019
This study investigates the potential of nucleus pulposus (NP)-like cells (NPCs) derived from human umbilical cord mesenchymal stem cells (MSCs) to restore degenerated intervertebral discs (IVDs) usin...
KEY FINDING: NPCs derived from MSCs expressed NP-specific genes (SOX9, ACAN, COL2, FOXF1, and KRT19).
Theranostics, 2018 • February 4, 2018
This study investigates the hemocompatibility of human white adipose tissue (WAT), umbilical cord (UC), and bone marrow stromal cells (BMSC) for safer cell transplantation. The study demonstrates that...
KEY FINDING: Bone marrow stromal cells (BMSCs) exhibit significantly lower tissue factor (TF) expression compared to white adipose tissue (WAT) and umbilical cord (UC) stromal cells.
Stem Cells International, 2018 • February 4, 2018
This review discusses the application of iPSCs in SCI treatment, focusing on their tumorigenicity. It explains the two types of tumorigenicity: teratoma formation and substantial tumor formation, high...
KEY FINDING: Tumorigenicity of iPSCs can be classified into two types: teratomas, which arise from undifferentiated cells, and true tumors, which are often malignant and can metastasize.
International Journal of Molecular Sciences, 2018 • March 15, 2018
The study investigates the therapeutic potential of mesenchymal stem cell-conditioned medium (MScCM) delivered intrathecally for spinal cord injury (SCI) recovery in rats. Results showed that MScCM tr...
KEY FINDING: Rats treated with intrathecal MScCM showed significantly higher motor function recovery compared to vehicle-treated rats after spinal cord injury.
Methods Mol Biol, 2018 • January 1, 2018
The article describes the collection and transplantation of adult rat primary SCs into the injured spinal cord, including tissue culture procedures and surgical methods for spinal cord injury inductio...
KEY FINDING: Schwann cell transplants can promote axonal regeneration in the injured spinal cord.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018 • January 18, 2018
This study compared the therapeutic efficacy of dermal papilla cells (DPCs) and bone marrow mesenchymal stem cells (BMSCs) in repairing spinal cord injuries (SCIs) in a rat model. The results demonstr...
KEY FINDING: DPC grafts exhibited enhanced lesion filling and survival compared with BMSC grafts on days 14 and 21 post‑transplantation.
Front. Cell. Neurosci., 2018 • March 9, 2018
The review focuses on the reciprocal relationship between adult neurogenesis, cognitive, and motor functions in the context of neurodegenerative disorders like Huntington's disease (HD). It introduces...
KEY FINDING: Reactive neuroblastosis, characterized by the abnormal proliferation and migration of neuroblasts towards the degenerating striatum, is observed in HD brains.
Sci Signal, 2018 • April 3, 2018
This study showed that nociceptin/ ORL1 signaling limits neural repair. ORL1 expression promoted glycosylation and surface expression of NgR1 to mediate inhibition of axonal regeneration by myelin-ass...
KEY FINDING: ORL1 expression promoted glycosylation and surface expression of NgR1 to mediate inhibition of axonal regeneration by myelin-associated inhibitors.