Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,751-1,760 of 2,298 results
Scientific Reports, 2018 • March 15, 2018
This study investigates the use of lentiviral vectors encoding NgR1-shRNA to decrease NgR1 expression and promote nerve regeneration and functional recovery after SCI in rats. The results indicated th...
KEY FINDING: Rats treated with LV-NgR1 shRNA showed significantly elevated BBB scores from 6 to 8 weeks after SCI, indicating improved motor function compared to the control group.
Neural Regen Res, 2018 • March 1, 2018
This study investigated the role of the protocadherin alpha (Pcdhα) cluster in axon growth and myelination in the developing central nervous system. The researchers found that deletion of the Pcdhα cl...
KEY FINDING: Axon length was significantly decreased in Pcdhα mutant neurons compared to wild-type neurons in culture.
Neural Regeneration Research, 2018 • March 1, 2018
This study investigated the efficacy of chitosan, sodium alginate, and composite chitosan-sodium alginate scaffolds in promoting spinal cord injury repair in rats with spinal cord hemisection. The res...
KEY FINDING: Chitosan scaffolds promoted the recovery of locomotor capacity and nerve transduction in experimental rats, as evidenced by Basso-Beattie-Bresnahan locomotor rating scale scores and electrophysiological results.
Neural Regen Res, 2018 • March 1, 2018
This study aimed to investigate gene expression differences in the injured spinal cord between aged and young mice using microarray data. The study identified shared and unique differentially expresse...
KEY FINDING: Aged mice showed a higher number of differentially expressed genes (DEGs) after SCI compared to young mice.
Experimental & Molecular Medicine, 2018 • April 20, 2018
This study investigated the reparative ability and therapeutic potentials of biological bridges composed of human fetal brain-derived NPCs seeded upon poly(glycolic acid)-based scaffold implanted into...
KEY FINDING: hNPC–scaffold complex transplantation effectively reduces infarct volume in HI brain injury and shows significant neuroprotection against SCI.
Cell Stem Cell, 2018 • July 5, 2018
The article reviews the conflicting evidence surrounding adult hippocampal neurogenesis in humans, triggered by two recent publications reaching opposite conclusions. It discusses the methodologies us...
KEY FINDING: Adult neurogenesis can be detected in the human hippocampus in the same location and numbers as expected based on work in rats, as indicated by the presence of BrdU-positive neurons.
Developmental Neurobiology, 2018 • May 11, 2018
This review examines the dorsal column lesion model of spinal cord injury, focusing on its utility in studying neuron-intrinsic regenerative responses. It discusses the advantages and disadvantages of...
KEY FINDING: Peripheral nerve injury induces a strong regenerative response in DRG neurons, while central branch injury does not, highlighting the importance of neuron-intrinsic factors.
Regeneration, 2018 • May 1, 2018
This review explores axonal regeneration in the zebrafish spinal cord, focusing on the events following spinal cord injury (SCI) and the subsequent repair mechanisms. It compares axonal regeneration i...
KEY FINDING: Adult zebrafish are capable of regenerating axonal tracts and restoring full functionality after SCI, unlike adult mammals where axon regeneration in the CNS is limited.
Neurotherapeutics, 2018 • May 4, 2018
Spinal cord injury (SCI) leads to tissue loss, inflammation, and functional impairments. Macrophages contribute to the inflammatory response, while mesenchymal stem cells (MSCs) have shown potential f...
KEY FINDING: MSCs secrete factors that promote neuroprotection, angiogenesis, and stabilization of the spinal cord-blood barrier, contributing to anatomical repair and functional recovery after spinal cord injury.
Trends Mol Med, 2018 • June 1, 2018
The review discusses a study that attenuating pericyte-derived fibrotic scarring promotes axon regeneration and functional recovery after spinal cord injury. The researchers used an inducible Cre tran...
KEY FINDING: Attenuation of pericyte-derived fibrotic scarring promotes axon regeneration and functional recovery after spinal cord injury.