Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,731-1,740 of 2,298 results
Stem Cells International, 2017 • December 3, 2017
This study aimed to evaluate the efficacy of gellan gum (functionalized with a fibronectin peptide), collagen, and NVR-gel in supporting the viability, metabolic activity, and gene expression of adipo...
KEY FINDING: All hydrogels supported ASC survival and viability, with functionalized GG hydrogels showing the most evident support.
Scientific Reports, 2018 • January 17, 2018
Results from this study reveal several key findings. First, these data reinforce lessons from the recent publication of the lamprey genome, which is that the lamprey CNS expresses homologs of a large ...
KEY FINDING: SCI in lamprey induces expression of many transcripts associated with regeneration in the mammalian PNS, illustrating the power of this organism as a model for identifying and studying highly conserved, fundamental, pro-regenerative molecular pathways.
Frontiers in Cellular Neuroscience, 2018 • February 27, 2018
This study compares the expression of Musashi (Msi) proteins in the spinal cord ependymal cells of Xenopus laevis and Ambystoma mexicanum at different life stages and during regeneration. The researc...
KEY FINDING: Msi-1 expression is high in regeneration-competent Xenopus tadpoles and is upregulated after injury in adult Axolotls, indicating its importance for spinal cord regeneration.
Scientific Reports, 2018 • January 22, 2018
The study evaluates the neurorestorative effects of an engineered HGF with a collagen binding domain (CBD-HGF) alone and in combination with gelatin-FA hydrogel for spinal cord injury (SCI) treatment ...
KEY FINDING: CBD-HGF has a higher binding affinity to spinal cord tissue and gelatin-FA hydrogel compared to unmodified HGF, allowing it to remain in the spinal cord longer.
Neurosci. Bull., 2018 • January 22, 2018
This study investigates the role of miR-146b in sciatic nerve regeneration, demonstrating that miR-146b directly targets KLF7. Inhibition of miR-146b promotes Schwann cell proliferation, migration, an...
KEY FINDING: miR-146b directly targets KLF7 by binding to its 3'UTR, suppressing its expression.
Frontiers in Cellular Neuroscience, 2018 • January 11, 2018
This review assesses combinatorial strategies of biomaterial-supported cell transplantation to reconstruct lost host tissue physically, cellularly and chemically after SCI, to increase cell survival a...
KEY FINDING: Schwann cells, astrocytes, olfactory ensheathing cells, mesenchymal stem cells, and neural stem and progenitor cells have been used with biomaterial scaffolds to promote axonal regeneration.
Frontiers in Molecular Neuroscience, 2018 • January 12, 2018
This study profiled the responses to spinal cord injury both at transcriptome and translatome level, and find them to be highly uncoupled, highlighting the importance of post-transcriptional gene regula...
KEY FINDING: A substantial post-transcriptional regulation of gene expression occurs following spinal cord injury.
Brain Res, 2018 • May 1, 2018
The study investigated the efficacy of human glial restricted progenitors (hGRPs) in promoting axonal growth of different tracts after spinal cord injury (SCI) in rats. hGRP transplants enhanced axona...
KEY FINDING: Transplanted hGRPs survived better in rats with dorsal column lesions compared to those with hemisection injuries.
Neural Regen Res, 2018 • January 1, 2018
This review summarizes experimental evidence that reveals novel roles for Wnt signaling in the injured CNS, and discusses possible mechanisms by which Wnt ligands could overcome molecular barriers inh...
KEY FINDING: Activation of Wnt/β-catenin signaling in retinal neurons and radial glia promotes neuronal survival and axonal growth.
Exp Neurol., 2018 • May 1, 2018
This study investigated the potential of cRheb to promote regeneration of injured respiratory axons after cervical spinal cord injury (SCI) in rats. The researchers found that cRheb expression in rVRG...
KEY FINDING: Expression of cRheb selectively in rVRG neurons following cervical hemisection SCI stimulates mTOR pathway activation within transduced cells.