Regenerative Medicine Research

KEY FINDING: hUC-MSC sheets demonstrated a greater capacity to promote vascular formation and newborn neuron regeneration at the SCI site compared to individual hUC-MSCs.

KEY FINDING: Recovery of damaged facial nerves was faster in rats whose severed nerves were sutured compared to those with partially resected nerves.

KEY FINDING: hAECs exhibited uniform distribution and attachment to the scaffold. In vitro differentiation analyses showed increased expression of Calca, Fox3, MBP, and GFAP genes.

KEY FINDING: Targeted therapies show promise in enhancing myelin repair after SCI by modulating key molecules and signaling pathways.

KEY FINDING: Norepinephrine axons in the adult mouse brain can regrow following injury induced by DSP4.

KEY FINDING: Scar resection enhances the local microenvironment by increasing neuroprotective microglia and macrophages, while reducing inhibitory factors that prevent axonal regeneration.

KEY FINDING: Low-modulus GelMA hydrogels promote cell migration, viability, and proliferation of co-cultured NSCs and BMSCs in vitro.

KEY FINDING: PI3Kd treatment increased sprouting of axons across the midline above the C4 lesion and reduced the number and distance of retraction bulbs from the lesion border.

KEY FINDING: The nanofiber felt promotes M2 macrophage polarization, reducing inflammation and oxidative stress.

KEY FINDING: MSCs and MSC-EVs reduce BSCB permeability after SCI, promoting vascular stability and functional recovery in preclinical models.