Bioinspired conductive oriented nanofiber felt with efficient ROS clearance and anti-inflammation for inducing M2 macrophage polarization and accelerating spinal cord injury repair

Bioactive Materials, 2025 · DOI: https://doi.org/10.1016/j.bioactmat.2024.12.009 · Published: December 6, 2024

Spinal Cord Injury Regenerative Medicine Biomedical

Simple Explanation

This study introduces a new material designed to help repair spinal cord injuries. It's a special type of nanofiber felt that can conduct electricity and reduce inflammation. The material is made to clear harmful substances (ROS) from the injury site, encourage a type of immune cell (M2 macrophages) that helps in healing, and promote nerve regeneration. By mimicking the body's natural processes, this innovative material aims to improve recovery from spinal cord injuries by creating a better environment for nerve cells to regrow.

Study Duration

8 Weeks (in vivo)

Participants

SD rats with complete transection SCI

Evidence Level

Not specified

Key Findings

1
The nanofiber felt promotes M2 macrophage polarization, reducing inflammation and oxidative stress.
2
It recruits endogenous neural stem cells (NSCs) and induces their differentiation into neurons.
3
The material enhances angiogenesis, remyelination, and neurological functional recovery in SCI rats.

Research Summary

This study presents a bioinspired conductive oriented nanofiber felt designed to treat complete spinal cord injury (SCI) by promoting neural regeneration and suppressing inflammation. The nanofiber felt incorporates a Fe3+-PDA-PAT chelate, enhancing its antioxidant, antibacterial, and hemostatic properties, thereby regulating the immune microenvironment of SCI. In vivo experiments on SCI rats demonstrated that the nanofiber felt effectively inhibits inflammation, promotes nerve regeneration, and enhances motor and functional recovery.

Practical Implications

Clinical Application

The bioinspired nanofiber felt holds great promise for clinical treatment of complete SCI due to its ability to inhibit inflammatory response and accelerate nerve regeneration.

Immunomodulatory Biomaterials Design

This study provides a novel strategy for designing immunomodulatory biomaterials tailored for SCI repair, addressing the complex immunopathological microenvironment at SCI sites.

Nerve Regeneration

The nanofiber felt's ability to recruit endogenous NSCs and induce their differentiation into neurons offers a pathway for reconstructing damaged neural circuits in SCI patients.

Bioinspired conductive oriented nanofiber felt with efficient ROS clearance and anti-inflammation for inducing M2 macrophage polarization and accelerating spinal cord injury repair

Simple Explanation

Key Findings

Research Summary

Practical Implications

Clinical Application

Immunomodulatory Biomaterials Design

Nerve Regeneration

Study Limitations

Your Feedback

Was this summary helpful?

Bioinspired conductive oriented nanofiber felt with efficient ROS clearance and anti-inflammation for inducing M2 macrophage polarization and accelerating spinal cord injury repair

Simple Explanation

Key Findings

Research Summary

Practical Implications

Clinical Application

Immunomodulatory Biomaterials Design

Nerve Regeneration

Study Limitations

Your Feedback

Was this summary helpful?