Targeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies

Spinal cord injury (SCI) is a severe condition that impairs motor, sensory, and autonomic functions. It is a major cause of disability due to the limited regeneration and remyelination of nerve fibers. Recent research has focused on understanding the molecular and cellular processes involved in remyelination. These advancements have paved the way for new therapeutic approaches aimed at promoting myelin repair and functional recovery after SCI. Targeted therapies, including pharmacological agents and biological factors, show promise in enhancing myelin repair after SCI. These therapies promote the proliferation and differentiation of oligodendrocyte precursor cells, which are essential for myelin sheath formation.

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  Targeted therapies show promise in enhancing myelin repair after SCI by modulating key molecules and signaling pathways.
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  Specific pharmacological agents and biological factors can effectively promote oligodendrocyte precursor cell proliferation, differentiation, and myelin sheath formation in both in vitro and in vivo models.
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  The review highlights the potential of targeted remyelination therapies as a promising strategy for SCI treatment, paving the way for future clinical applications.