Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,421-1,430 of 2,298 results
Theranostics, 2025 • January 2, 2025
This study investigates the mechanisms behind stem cell transplantation in spinal cord injury (SCI) repair in large animals without immunosuppressive drugs (ISD). The research demonstrates that short-...
KEY FINDING: hscNPCs remodeled the injury microenvironment shortly after transplantation by reducing inflammation and enhancing angiogenesis, leading to increased endogenous neuronal regeneration.
ASN NEURO, 2025 • January 1, 2025
Functional recovery following spinal cord injury will require the regeneration and repair of damaged neuronal pathways. Neurons in the brain and spinal cord are a diverse group of cells with many popu...
KEY FINDING: The neuronal response to injury is variable, based on multiple factors, including the location of the injury with respect to the neuronal cell bodies and the affected neuronal populations.
Front. Cell. Neurosci., 2025 • January 3, 2025
This study investigates the therapeutic potential of Cycloastragenol (CAG) in promoting dorsal column axon regeneration in mice following spinal cord injury (SCI). The researchers established a novel ...
KEY FINDING: Intraperitoneal injections of cycloastragenol (CAG) significantly promoted the growth of in vitro-cultured dorsal root ganglion (DRG) axons.
Cells, 2025 • January 7, 2025
This study provides the first direct transcriptomic and functional comparison of syngeneic adult human NSPC populations, including bona fide spinal cord NSPCs and iPSC-derived NSPCs regionalized to th...
KEY FINDING: iPSC-Br NSPCs exhibit a closer resemblance to bona fide spinal cord NSPCs, characterized by enriched expression of neurogenesis, axon guidance, synaptic signaling, and voltage-gated calcium channel activity pathways.
Int. J. Mol. Sci., 2025 • January 16, 2025
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising therapeutic strategy for spinal cord injury (SCI) due to their unique properties like low immunogenicity and ...
KEY FINDING: MSC-EVs have been demonstrated to exert multiple beneficial effects in SCI, including reducing inflammation, promoting neuroprotection, and enhancing axonal regeneration.
Biomater Transl, 2024 • November 15, 2024
Stem cell-derived spinal cord organoids (SCOs) have revolutionised the study of spinal cord development and disease mechanisms, offering a three-dimensional model that recapitulates the complexity of ...
KEY FINDING: SCOs effectively model spinal cord morphogenesis, offering insights into the intricate processes of neural tube formation and regional specification.
Bioactive Materials, 2025 • December 27, 2024
This study developed a 3D bioprinted dynamic living construct that modulates encapsulated NSCs to self-organize into a functional neural network for spinal cord injury repair. The ECM-mimicking bioink...
KEY FINDING: The dynamic properties of the 3D bioprinted living fibers alleviate mechanical confinement on NSCs, enhancing their mechanosensing, spreading, migration, and matrix remodeling.
Molecular Neurodegeneration, 2025 • January 23, 2025
This study aimed to identify transcription factor (TF) combinations that could activate regeneration-associated genes (RAGs) and promote axon regeneration after spinal cord injury. Through in vitro sc...
KEY FINDING: Promoter analysis identified ATF3, Jun, CEBPD, KLF7, MEF2, SMAD1, SOX11, STAT3 and SRF as candidate RAG-activating TFs.
Brain and Spine, 2025 • January 23, 2025
This study comprehensively examines the temporospatial dynamics of vascular injury and regeneration following experimental spinal cord injury (SCI) in mice, focusing on changes in vascular density, pe...
KEY FINDING: Vascular injury is most severe initially at the epicenter and spreads to surrounding spinal cord regions, with a delayed vascular loss observed in peritraumatic regions.
Molecules, 2025 • January 22, 2025
This study presents a novel MXene-reinforced composite cryogel scaffold for neural tissue regeneration, leveraging MXene's conductivity and biocompatibility within a PVA matrix. The MXene/PVA cryogel ...
KEY FINDING: The MXene/PVA cryogel is cytocompatible and supports neural cell proliferation. Embedded MXenes did not inhibit cell growth; rather, they stimulated cell proliferation by 15–44%.