Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,401-1,410 of 2,298 results
Cell Death Discovery, 2024 • October 25, 2024
This study maps chromatin accessibility during human somatic reprogramming to naïve and primed pluripotency, delineating distinct cell fate trajectories. PRDM1 is identified as a crucial transcription...
KEY FINDING: PRDM1α and PRDM1β bind to distinct genomic loci and play different roles in the naïve reprogramming process.
eLife, 2023 • November 22, 2023
This study combines transcriptomic profiling using DNA microarrays and large-scale scRNAseq to analyze the molecular and cellular changes during SVZ neurogenesis. It identifies and characterizes immat...
KEY FINDING: iNBs are a molecularly distinct class of SVZ cells, exhibiting features of both neural progenitors and neuroblasts, while retaining regenerative capacity and plasticity.
Advanced Science, 2025 • November 25, 2024
This study introduces a novel COCu-Tac-iNSCs transplantation system to address challenges in cell-based therapies for spinal cord injury, such as graft rejection and mitochondrial dysfunction. The sel...
KEY FINDING: The COCu-Tac hydrogel promotes the survival and neuronal differentiation of transplanted iNSCs without systemic immunosuppression, leading to improved outcomes compared to iNSCs alone.
Biology, 2024 • November 20, 2024
This study investigated the efficiency of combining heterologous fibrin biopolymer (HFB) for reimplantation, mesenchymal stem cell (MSC) therapy, and dimethyl fumarate (DMF) administration in treating...
KEY FINDING: The combined therapy resulted in a reduced glial response and a 70% improvement in behavioral motor recovery.
Molecules, 2024 • November 14, 2024
This study aimed to develop and characterize three-dimensional chitosan-based cellular scaffolds for nervous tissue regeneration, utilizing chitosan, l-Aspartic acid, l-Glutamic acid, propylene glycol...
KEY FINDING: The addition of poly(dopamine) and CBD significantly impacted the scaffolds’ swelling properties and structural stability.
Stem Cell Research & Therapy, 2024 • November 22, 2024
Spinal cord injury (SCI) involves a continuous and dynamic cascade of complex reactions, with mitochondrial damage and dysfunction-induced energy metabolism disorders playing a central role throughout...
KEY FINDING: Mitochondrial transplantation (MT) reduces neuronal death and promotes axonal regeneration after spinal cord injury by regulating the MAPK/ERK and PI3K/Akt signaling pathways.
Military Medical Research, 2024 • January 1, 2024
This review focuses on the mechanisms through which BAPPs influence the microenvironment for tissue repair via reactive oxygen species, blood and lymphatic vessels, immune cells, and repair cells. A v...
KEY FINDING: BAPPs modulate the tissue microenvironment by influencing reactive oxygen species (ROS), blood and lymphatic vessels, immune cells, and repair cells, creating a customizable approach to tissue regeneration at specific anatomical sites.
Global Spine Journal, 2024 • January 1, 2024
This study evaluated the effects of different doses of erythropoietin (EPO) and magnitudes of trauma on neural regeneration in rats with spinal cord injuries. Rats were subjected to varying degrees of...
KEY FINDING: Animals receiving a higher dose of erythropoietin (5000 IU/kg) and suffering minor trauma (12.5 mm impact height) showed better and faster neurological recovery.
eLife, 2024 • December 12, 2024
The study identifies Marcks and Marcksl1 as essential proteins for spinal cord development and regeneration in Xenopus laevis. Loss-of-function experiments demonstrated that Marcks and Marcksl1 are re...
KEY FINDING: Marcks and Marcksl1 are required for normal neurite formation during spinal cord development, acting redundantly.
Advanced Healthcare Materials, 2025 • December 12, 2024
The study evaluated an rGO-based nanocomposite supported by adipose decellularized ECM for spinal cord injury repair. The nanocomposite evoked a tissue-regenerative response, demonstrating the potenti...
KEY FINDING: adECM-rGO nanocomposites completely restored the integrity of the spinal cord after hemisection SCI in rats.