Histological effects of combined therapy involving scar resection, decellularized scaffolds, and human iPSC-NS/PCs transplantation in chronic complete spinal cord injury

Chronic spinal cord injuries are hard to treat due to scar tissue. This study tested a new approach combining surgery to remove scar tissue, a supportive gel made from decellularized kidney tissue, and transplantation of special cells (iPSC-NS/PCs). The kidney-derived gel was chosen because it's compatible with the body and encourages blood vessel growth, which is important for healing. Tests showed it helps nerve cells grow. The combined treatment showed promise in lab rats with spinal cord injuries. It improved the environment around the injury, helped transplanted cells survive, and encouraged the regrowth of the rats' own nerve fibers.

• 1
  Scar resection enhances the local microenvironment by increasing neuroprotective microglia and macrophages, while reducing inhibitory factors that prevent axonal regeneration.
• 2
  The combination of scar resection and dECM hydrogel further promoted vascular endothelial cell migration.
• 3
  The integrated approach of scar resection, dECM hydrogel scaffolding, and hNS/PC transplantation has been proven to be a more effective treatment strategy for chronic SCI.